本文選題：乙醇 + 亞低溫��； 參考：《蘭州大學(xué)》2013年碩士論文

【摘要】：目的：心肺復(fù)蘇成功后存活患者中仍有40%-50%出現(xiàn)不同程度的神經(jīng)功能障礙,本實(shí)驗(yàn)研究乙醇聯(lián)合亞低溫對(duì)心臟驟停后腦組織的保護(hù)作用,為心臟驟停后腦復(fù)蘇提供新理論、新方法。方法：通過(guò)體外致顫法建立家兔心肺復(fù)蘇模型,80只家兔隨機(jī)分為五組,每組16只,分別為假手術(shù)組(A組)、復(fù)蘇組(B組)、局部亞低溫組(C組)、乙醇組(D組)、乙醇聯(lián)合局部亞低溫組(E組)。B組于復(fù)蘇成功后即刻頸內(nèi)靜脈滴注生理鹽水,C組復(fù)蘇成功后即刻實(shí)施頭部局部亞低溫,將冰塊置于家兔的頭部、頸部,迅速將鼓膜溫度降至32℃-34℃后持續(xù)維持體溫至實(shí)驗(yàn)結(jié)束。D組復(fù)蘇成功后即刻頸內(nèi)靜脈滴注1.5g/kg乙醇(滴注時(shí)間10min),E組復(fù)蘇成功后即刻頭部實(shí)施亞低溫+頸內(nèi)靜脈滴注1.5g/kg乙醇(滴注時(shí)間10min)。實(shí)驗(yàn)過(guò)程中持續(xù)監(jiān)測(cè)平均動(dòng)脈壓(MAP≥80mmHg),維持至實(shí)驗(yàn)結(jié)束。復(fù)蘇后12小時(shí)測(cè)定血中S100β蛋白含量、腦組織含水量、腦壞死體積。結(jié)果：B組血中S100β蛋白含量、腦組織含水量、腦壞死體積較各治療組顯著增高,E組各項(xiàng)指標(biāo)檢測(cè)較C組、D組低(P0.05)。結(jié)論：乙醇聯(lián)合亞低溫治療對(duì)心臟驟停后腦組織具有一定程度的協(xié)同保護(hù)作用。
[Abstract]:Objective: 40% to 50% of the surviving patients after cardiopulmonary resuscitation (CPR) had different degrees of neurological dysfunction. This study was designed to study the protective effect of ethanol combined with mild hypothermia on brain tissue after cardiac arrest in order to provide a new theory for brain resuscitation after cardiac arrest. New method Methods: 80 rabbits with cardiopulmonary resuscitation were randomly divided into five groups with 16 rabbits in each group. Group A of sham operation, group B of resuscitation, group C of local mild hypothermia, group D of ethanol, group E of ethanol combined with local mild hypothermia were treated with saline immediately after resuscitation. Immediate local mild hypothermia of the head, Place the ice on the head and neck of the rabbit, Quickly drop the tympanic membrane temperature to 32 鈩，

本文編號(hào)：1868436