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nCPAP干預(yù)治療對(duì)非急性期腦梗死合并OSAHS患者神經(jīng)功能的影響

發(fā)布時(shí)間:2018-04-26 03:25

  本文選題:持續(xù)氣道正壓通氣 + 腦梗死; 參考:《重慶醫(yī)學(xué)》2016年06期


【摘要】:目的探討經(jīng)鼻持續(xù)氣道正壓通氣(nCPAP)干預(yù)治療對(duì)非急性期腦梗死(CI)合并阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)患者神經(jīng)功能的影響。方法 68例患者經(jīng)頭顱CT或MRI確診為CI且處于非急性期后,經(jīng)多導(dǎo)睡眠圖(PSG)診斷為OSAHS,將其分為觀察組和對(duì)照組,對(duì)照組給予神經(jīng)內(nèi)科常規(guī)治療,觀察組在對(duì)照組基礎(chǔ)上給予每晚大于4h的nCPAP呼吸機(jī)治療,分別于治療后1、3、6個(gè)月時(shí)根據(jù)美國(guó)國(guó)立衛(wèi)生研究院卒中量表(NIHSS)對(duì)患者進(jìn)行神經(jīng)功能評(píng)分,愛(ài)潑沃斯嗜睡量表(ESS)進(jìn)行嗜睡評(píng)分及用標(biāo)準(zhǔn)吞咽功能評(píng)定量表(SSA)進(jìn)行吞咽功能評(píng)分。結(jié)果 nCPAP呼吸機(jī)治療的觀察組ESS評(píng)分下降,NIHSS評(píng)分上升,與對(duì)照組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05);而SSA評(píng)分與對(duì)照組比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論nCPAP治療可有效改善非急性期CI合并OSAHS患者癥狀,使其神經(jīng)功能恢復(fù),是臨床一種藥物以外的有效方法。
[Abstract]:Objective to investigate the effect of nasal continuous positive airway pressure (CPAP) intervention on neurologic function in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) after non-acute cerebral infarction (CI). Methods 68 patients with CI diagnosed by CT or MRI were diagnosed as OSAHS by polysomnography (PSG). They were divided into observation group and control group. The observation group was treated with nCPAP ventilator for more than 4 hours per night on the basis of the control group. The patients were assessed according to the National Institutes of Health Stroke scale (NIHSS) at 1 and 6 months after treatment. Epworth sleepiness scale (ESS) and standard swallowing function scale (SSAs) were used to evaluate somnolence. Results the ESS score of the nCPAP ventilator group decreased and the NIHSS score increased, which was significantly higher than that of the control group (P 0.05), but the SSA score was not significantly different from that of the control group (P 0.05). Conclusion nCPAP treatment can effectively improve the symptoms of CI patients with OSAHS in non-acute stage and restore their neurological function. It is an effective method in addition to clinical drugs.
【作者單位】: 廣東醫(yī)學(xué)院第二附屬醫(yī)院呼吸內(nèi)科;
【基金】:2013年湛江市財(cái)政資金科技專項(xiàng)競(jìng)爭(zhēng)性分配項(xiàng)目(2013A01017)
【分類號(hào)】:R743.3;R766

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