本文選題：尿膿毒血癥 + 降鈣素原��； 參考：《重慶醫(yī)科大學(xué)學(xué)報(bào)》2014年06期

【摘要】：目的:探討血清降鈣素原(procalcitonin,PCT)在診斷尿膿毒血癥中的臨床意義。方法:41例尿膿毒血癥患者為尿膿毒血癥組,79例普通泌尿道感染患者對照組,檢測2組患者PCT、超敏C反應(yīng)蛋白(hypersensitive C-reactive protein,hs-CRP)、白細(xì)胞(white blood cells,WBC)及中性粒細(xì)胞水平;繪制受試者工作特征(receiver operating characteristic,ROC)曲線,評(píng)價(jià)PCT及相關(guān)炎癥指標(biāo)鑒別尿膿毒血癥高�；颊叩哪芰�,并對PCT與hs-CRP、WBC及中性粒細(xì)胞進(jìn)行雙變量相關(guān)性分析。結(jié)果:與對照組比較,尿膿毒癥組PCT濃度(μg/L)、hs-CRP(mg/L)、WBC(×109個(gè)/L)及中性粒細(xì)胞(×109個(gè)/L)均明顯增高(PCT濃度:3.113±1.953 vs.0.057±0.0550;hs-CRP:18.820±15.460 vs.7.440±14.520;WBC:12.860±4.002 vs.8.150±4.630;中性粒細(xì)胞:90.335±3.975 vs.74.30±15.40),差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。ROC曲線分析顯示,PCT的曲線下面積(area under the curve,AUC)為1,高于hs-CRP、WBC、中性粒細(xì)胞(AUC分別為0.813、0.875、0.984);且PCT為2.000μg/L時(shí),敏感性為90.2%,特異性為100%,優(yōu)于其他傳統(tǒng)炎癥指標(biāo)。雙變量相關(guān)性分析顯示,PCT與WBC和中性粒細(xì)胞數(shù)均呈顯著正相關(guān),分別為(rs=0.609,P=0.000;rs=0.057,P=0.000),而與hs-CRP有相關(guān)性(rs=0.213,P=0.020)。結(jié)論:PCT在診斷尿膿毒血癥具有較高的敏感度和特異度,有助于尿膿毒血癥的早期診斷及早期治療。
[Abstract]:Objective: to investigate the clinical significance of serum procalcitonin (PCT) in the diagnosis of urinary sepsis. Methods 41 patients with urosepsis were divided into two groups: urosepsis group (n = 79) and urinary tract infection group (n = 79). The levels of PCT, hypersensitive C-reactive protein hs-CRP, white blood cells and neutrophils in two groups were detected. The receiver operating characteristic curve was drawn to evaluate the ability of PCT and related inflammatory indexes to distinguish high risk patients with urinary sepsis, and the correlation between PCT and hs-CRP WBC and neutrophils was analyzed. Results: compared with the control group, 灝胯創(chuàng)姣掔棁緇凱CT嫻撳害(渭g/L),hs-CRP(mg/L),WBC(脳109涓，

本文編號(hào)：1802348