本文選題：急性腦梗死 + 不寧腿綜合征　； 參考：《南昌大學(xué)》2014年碩士論文

【摘要】：目的：分析急性腦梗死后出現(xiàn)不寧腿綜合征（restless legs syndrome,RLS）的患病率以及其臨床特點(diǎn)。分析急性腦梗死后RLS對(duì)梗死的預(yù)后及轉(zhuǎn)歸的影響，為急性腦梗死的治療及康復(fù)提供新思路。 方法：本研究選取2012年5月-2013年5月期間275例急性腦梗死患者，其中符合國際RLS診斷標(biāo)準(zhǔn)診斷及多巴胺試驗(yàn)陽性患者為RLS組，按RLS患者的年齡、性別及梗死部位篩選出條件匹配的急性腦梗死未出現(xiàn)RLS的患者為非RLS組。RLS組患者均行多導(dǎo)睡眠圖檢查（polysomnographic，，PSG），予以普拉克索（25mg/次，每晚一次）治療，分析急性腦梗死后RLS中可能相關(guān)危險(xiǎn)因素及臨床特點(diǎn)，對(duì)RLS組與非RLS組患者患病7天內(nèi)以及預(yù)后90天、180天的臨床康復(fù)情況進(jìn)行比較。 結(jié)果：275例急性腦梗死患者符合入選標(biāo)準(zhǔn)，其中RLS組患者19例（19/275，6.91%），年齡62.89±10.26歲；非RLS組，年齡62.63±9.96。在RLS組，RLS癥狀出現(xiàn)時(shí)間平均在卒中后1.68±0.82天，6例（31.6%）出現(xiàn)在梗死部位支配側(cè)肢體，13例（68.4%）雙下肢出現(xiàn)；急性腦梗死部位不同出現(xiàn)RLS的患病率有所不同。RLS組與非RLS組比較示RLS組的血紅蛋白含量較低，日間過度睡眠（ESS10)（χ2=5.40，P=0.02），RLS組（11/19，57.9%）高于非RLS組（4/19，21.1%），主觀睡眠質(zhì)量差（PSQI15）（χ2=4.39，P=0.04），RLS組（9/19，47.4%）高于非RLS組（3/19，15.8%）。在RLS組，中重呼吸暫停綜合征（OSAHS，AHI15）的患病率為9/19（47.4%），周期性腿動(dòng)重度（PLMS，PLMSI25）的患病率為68.42%（13/19），對(duì)比梗死后90天及180天的BI及mRS示RLS組不及非RLS組。 結(jié)論：急性腦梗死后不寧腿綜合征的發(fā)病機(jī)理與多巴胺能神經(jīng)元及中樞感覺運(yùn)動(dòng)神經(jīng)通路受損有關(guān)。梗死后RLS患者易出現(xiàn)日間疲勞及主觀嗜睡，較非RLS組預(yù)后差。
[Abstract]:Objective: to analyze the prevalence and clinical characteristics of restless legs syndrome after acute cerebral infarction. To analyze the influence of RLS on the prognosis and prognosis of acute cerebral infarction (ACI) and to provide new ideas for the treatment and rehabilitation of acute cerebral infarction (ACI). Methods: 275 patients with acute cerebral infarction (ACI) from May 2012 to May 2013 were selected as RLS group according to the age of RLS patients. The patients without RLS in the non-RLS group who were screened out by sex and infarct location were all treated with polysomnographicus PSG by polysomnography, which were treated with Praxol 25mg / time, once a night, and the patients in the RLS group were all treated with polysomnography. To analyze the possible risk factors and clinical characteristics of RLS after acute cerebral infarction, and to compare the clinical rehabilitation of RLS group with that of non- group within 7 days and the prognosis of 90 days to 180 days. Results one hundred and seventy-five patients with acute cerebral infarction met the inclusion criteria, including 19 patients with 19 / 2756.91 and 62.89 鹵10.26 years of age in RLS group, and 62.63 鹵9.96 in non- group. In the RLS group, the mean onset time of RLS symptoms was 1.68 鹵0.82 days after stroke in 6 cases (31.6%). The prevalence of RLS was different between RLS group and non-RLS group. The hemoglobin content in RLS group was lower than that in non-RLS group. The incidence of RLS in RLS group was higher than that in non- group (蠂 2 5.40 P 0.02 0. 02%) higher than that in non- group. The subjective sleep quality of RLS group was lower than that of non- group. In the RLS group, the prevalence of OSAHS AHI15 was 9 / 19 / 47.4, and the incidence of periodic leg movement was 68.42 / 19 / 19. The BI and mRS of 90 and 180 days after infarction showed that the RLS group was not as good as the non- group. Conclusion: the pathogenesis of restless leg syndrome after acute cerebral infarction is related to the damage of dopaminergic neurons and central sensory motor pathway. Day fatigue and subjective sleepiness were more common in patients with RLS after infarction than in non- group.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R743.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 趙華;劉智舒;姚長江;;偏頭痛的神經(jīng)科共病及相關(guān)機(jī)制探討[J];醫(yī)學(xué)綜述;2013年01期

2 李雪蓉;孫鵬;徐江濤;;不寧腿綜合征與缺血性腦血管病臨床相關(guān)性的研究進(jìn)展[J];醫(yī)學(xué)綜述;2013年14期

3 吳偉;薛蓉;;不寧腿綜合征[J];中國現(xiàn)代神經(jīng)疾病雜志;2013年05期

本文編號(hào)：1789997