本文選題：胞二磷膽堿 + 急性腦卒中��； 參考：《中國(guó)循證醫(yī)學(xué)雜志》2011年04期

【摘要】：目的評(píng)價(jià)胞二磷膽堿治療急性腦卒中的療效及安全性。方法計(jì)算機(jī)檢索PubMed、Cochrane圖書(shū)館、EMbase、Web of Science、CNKI、VIP和中華醫(yī)學(xué)會(huì)數(shù)字化期刊庫(kù),收集胞二磷膽堿治療急性腦卒中的隨機(jī)對(duì)照試驗(yàn),檢索時(shí)間均從建庫(kù)至2010年9月,并追查已獲文獻(xiàn)的參考文獻(xiàn)。按照納入標(biāo)準(zhǔn)由2名研究者獨(dú)立篩選文獻(xiàn)并提取資料,參照J(rèn)adad評(píng)分標(biāo)準(zhǔn)對(duì)納入文獻(xiàn)的方法學(xué)質(zhì)量進(jìn)行評(píng)估,而后采用RevMan 5.0軟件進(jìn)行Meta分析。結(jié)果共納入13個(gè)研究,共2837例患者。Meta分析結(jié)果顯示:與安慰劑相比,胞二磷膽堿治療急性腦卒中的遠(yuǎn)期病死率或依賴(lài)率差異無(wú)統(tǒng)計(jì)學(xué)意義[OR=0.94,95%CI(0.66,1.36),P=0.75];但胞二磷膽堿治療急性腦卒中的總有效率高于安慰劑,差異有統(tǒng)計(jì)學(xué)意義[OR=1.72,95%CI(1.41,2.10),P0.00001]。5個(gè)研究報(bào)道了胞二磷膽堿治療急性腦卒中的不良反應(yīng)發(fā)生率,不良反應(yīng)程度輕微,無(wú)嚴(yán)重不良反應(yīng)發(fā)生,臨床應(yīng)用安全。結(jié)論目前研究表明,胞二磷膽堿治療急性腦卒中的總有效率優(yōu)于安慰劑且安全性好,但無(wú)法降低遠(yuǎn)期(3個(gè)月)病死率或依賴(lài)率。
[Abstract]:Objective to evaluate the efficacy and safety of citicoline in the treatment of acute stroke.Methods We searched the library of EMbase of Science of CNKI VIP and the digital journal library of the Chinese Medical Association, collected the randomized controlled trial of citicoline in the treatment of acute cerebral apoplexy. The retrieval time was from the establishment of the library to September of 2010, and the references that had been obtained were followed up.According to the inclusion criteria, two researchers independently sifted the literature and extracted the data. The methodological quality of the included literature was evaluated according to the Jadad scoring criteria, and then the Meta analysis was carried out with RevMan 5.0 software.Results in 13 studies, 2837 patients. Meta-analysis showed: compared with placebo,There was no significant difference in the long-term mortality or dependence rate of citicoline in the treatment of acute stroke [OR0.9495], but the total effective rate of citicoline in the treatment of acute stroke was higher than that in placebo.There were significant differences in the incidence of adverse reactions in the treatment of acute cerebral apoplexy with citicoline 1.71% 2.10% (P 0.00001). The degree of adverse reactions was mild, no serious adverse reactions occurred, and the clinical application was safe.Conclusion the total effective rate of citicoline in the treatment of acute stroke is better than that of placebo, but it can not reduce the long-term (3 months) mortality or dependence rate.
【作者單位】： 蘭州大學(xué)第二臨床醫(yī)學(xué)院;蘭州大學(xué)第二醫(yī)院;
【分類(lèi)號(hào)】：R743.3

【參考文獻(xiàn)】

中國(guó)期刊全文數(shù)據(jù)庫(kù) 前10條

1 張國(guó)瑾;王笑中;肖鎮(zhèn)祥;;缺血性腦血管疾病某些藥物的臨床評(píng)價(jià)[J];國(guó)外醫(yī)學(xué).神經(jīng)病學(xué)神經(jīng)外科學(xué)分冊(cè);1986年01期

2 楊美納;曲敏;王卓爾;劉丹丹;;胞二磷膽堿治療腦血栓形成128例療效觀察[J];佳木斯醫(yī)學(xué)院學(xué)報(bào);1992年04期

3 姚雪鵬,董正坤,柴風(fēng)良,孫蘭香;胞二磷膽堿治療腦血管病意識(shí)障礙80例臨床觀察[J];臨床薈萃;1994年19期

4 劉學(xué)伍,邵忠民,遲兆富,吳偉,尚偉;急性腦梗死患者血清神經(jīng)特異性烯醇化酶的含量變化及尼可林對(duì)其的影響[J];腦與神經(jīng)疾病雜志;2004年02期

5 倪秀石;秦震;王玉霞;;胞二磷膽堿治療急性腦梗塞的隨機(jī)雙盲對(duì)照研究[J];上海醫(yī)學(xué);1991年03期

6 舒國(guó)長(zhǎng),周維華,李英梅;胞二磷膽堿治療急性腦卒中用藥時(shí)機(jī)和療效的探討[J];上海醫(yī)藥;2000年10期

7 朱秀云;陳亦斌;陳順泉;;胞二磷膽堿治療腦血管疾病的臨床觀察[J];實(shí)用內(nèi)科雜志;1989年04期

8 侯榮華;胞磷膽堿的臨床應(yīng)用[J];醫(yī)藥導(dǎo)報(bào);2003年S1期

9 江萬(wàn)青,潘必昌;加用胞二碘膽堿治療腦梗塞療效觀察[J];冶金醫(yī)藥情報(bào);1992年03期

10 ;各類(lèi)腦血管疾病診斷要點(diǎn)[J];中華神經(jīng)科雜志;1996年06期

【共引文獻(xiàn)】

中國(guó)期刊全文數(shù)據(jù)庫(kù) 前10條

1 劉劍波,史曉冬;香丹注射液對(duì)腦梗死患者血液流變學(xué)的干預(yù)作用[J];安徽中醫(yī)臨床雜志;2003年04期

2 黃俊臣,周紀(jì)平,李彥春;核桃承氣湯對(duì)腦梗死急性期輔助治療作用的觀察[J];安徽中醫(yī)臨床雜志;2003年04期

3 龐家善,李樹(shù)標(biāo),陳艷艷;自擬化痰祛瘀方治療急性腦梗死療效觀察[J];中醫(yī)藥臨床雜志;2004年01期

4 潘啟明,張松林,蘭小平;自擬偏癱方配合早期康復(fù)治療腦梗死偏癱56例臨床觀察[J];中醫(yī)藥臨床雜志;2004年02期

5 華卡;復(fù)方丹參注射液治療急性腦梗死臨床藥效分析[J];中醫(yī)藥臨床雜志;2004年04期

6 郭漢強(qiáng);醒腦凈合息風(fēng)通絡(luò)化痰湯對(duì)急性腦出血的治療作用[J];中醫(yī)藥臨床雜志;2004年05期

7 張波,鄭軍,鮑遠(yuǎn)程,蔡永亮,陳懷珍,王艷昕,王曉e，

本文編號(hào)：1759197