發(fā)布時(shí)間：2018-04-14 13:01

  本文選題：柴胡注射液 + 急性心肌梗死　； 參考：《東南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年03期

【摘要】：目的:考察柴胡注射液對(duì)接受經(jīng)皮冠狀動(dòng)脈介入(PCI)治療的急性心肌梗死(AMI)患者的臨床療效及可能機(jī)制。方法:收集接受PCI治療的AMI患者128例,分為觀察組和對(duì)照組各64例,觀察組在對(duì)照組治療基礎(chǔ)上給予柴胡注射液治療。于PCI術(shù)前、術(shù)后檢測超聲心動(dòng)、超敏C-反應(yīng)蛋白(hs-CRP),B型氨基端利鈉肽原(pro-BNP)、基質(zhì)金屬蛋白酶-9(MMP-9)、血清活性氧簇(ROS)、血管內(nèi)皮生長因子(VEGF),并隨訪1年。結(jié)果:PCI術(shù)后,兩組左室射血分?jǐn)?shù)(LVEF)、左室舒張末期內(nèi)徑(LVEDD)、左室收縮末期內(nèi)徑(LVESD)、左室舒張末容積(LVEDV)以及血清hs-CRP、BNP、MMP-9、ROS、VEGF水平較治療前降低(P0.05),LVEF較治療前增高(P0.05),呈時(shí)間依賴性升高;與對(duì)照組相比,觀察組心率、LVEDV、LVEDD、LVESD及血清hs-CRP、BNP、MMP-9、ROS、VEGF水平降低(P0.05),LVEF增高(P0.05);隨訪1年,兩組均無失訪病例,觀察組靶血管血運(yùn)重建和總惡性事件發(fā)生較對(duì)照組少(P0.05)。結(jié)論:柴胡注射液對(duì)接受PCI治療的AMI患者具有良好的效果,可能與改善心功能及降低氧化應(yīng)激有關(guān)。
[Abstract]:Objective: to investigate the clinical effect and possible mechanism of Chaihu injection in patients with acute myocardial infarction (AMI) treated by percutaneous coronary intervention (PCI).Methods: 128 AMI patients treated with PCI were divided into two groups: observation group (n = 64) and control group (n = 64).Before and after PCI, echocardiography, hypersensitive C-reactive protein (CRP) B type amino-terminal natriuretic peptide pro-BNPN, matrix metalloproteinase-9 (MMP-9), serum reactive oxygen species (Ros) and vascular endothelial growth factor (VEGF) were detected and followed up for 1 year.Results after PCI, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDDN), left ventricular end-systolic diameter (LVESDN), left ventricular end-diastolic volume (LVEDVV) and serum hs-CRPNP-MMP-9 rosiform VEGF levels in both groups were significantly lower than those before treatment, and LVEF was increased in a time dependent manner compared with that before treatment. The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEF) and left ventricular end-diastolic volume (LVEF) were increased in a time-dependent manner.Compared with the control group, the levels of HR, LVED, LVESD and serum hs-CRPNP-BNPMMP-9 / ROSS-VEGF in the observation group were significantly lower than those in the control group (P 0.05) and LVEF was higher than that in the control group (P 0.05), and there were no cases in the two groups after one year follow-up, and the incidence of target blood vessel revascularization and total malignant events in the observation group was less than that in the control group (P 0.05).Conclusion: Bupleurum injection has a good effect on AMI patients treated with PCI, which may be related to improving cardiac function and reducing oxidative stress.
【作者單位】： 即墨市人民醫(yī)院急診科;即墨市人民醫(yī)院心內(nèi)科;即墨市中醫(yī)醫(yī)院內(nèi)科;
【分類號(hào)】：R542.22
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本文編號(hào)：1749400