本文選題：心力衰竭 + 和肽素�。� 參考：《重慶醫(yī)科大學》2013年碩士論文

【摘要】：研究目的： 探討和肽素（copeptin）在急性失代償性心力衰竭（AcuteDecompensated Heart Failure， ADHF）患者90天內(nèi)發(fā)生不良事件的預測評估價值。 方法： 入選129例急性失代償性心力衰竭患者，，測定血漿和肽素、N末端B型利鈉肽原水平，采用心臟彩超測定左室射血分數(shù)，進行紐約心功能分級,并對所有患者連續(xù)隨訪90天，以心源性死亡或心力衰竭加重再入院為不良終點事件。評估和肽素對急性失代償性心力衰竭患者90天不良終點事件的預測價值，并與NT-proBNP進行比較。 結(jié)果： 終點事件組47人、非終點事件組82人。終點事件組血漿copeptin、NT-proBNP水平均明顯高于非終點事件組,差異有統(tǒng)計學意義（P 0.05）。受試者工作曲線下面積（Receiver operating characteristic，ROCs）分別為：copeptin0.602(SE，0.052；95%CI0.499-0.705)； NT-proBNP0.659(SE，0.048；95%CI0.565-0.753)；兩者聯(lián)合預測價值0.670(SE，0.050；95%CI0.573-0.767)，差異均無統(tǒng)計學意義（P㧐0.05）。 結(jié)論： 在急性失代償性心力衰竭患者中，血漿copeptin水平對于患者發(fā)生心血管不良事件有預后評估價值，隨訪90天內(nèi)血漿copeptin水平與NT-proBNP對預測不良終點事件價值相同，聯(lián)合應用copeptin、NT-proBNP不能提高急性失代償性心力衰竭患者90天的預后評估價值。
[Abstract]:Purpose of study :

To investigate the predictive value of copeptin in predicting adverse events within 90 days of patients with acute decompensated heart failure ( ADHF ) .

Method :

In 129 patients with acute decompensated heart failure , the levels of plasma and peptide , N - terminal B - type natriuretic peptide were measured , the left ventricular ejection fraction was measured by color Doppler ultrasound , the cardiac function in New York was graded , and the event of adverse endpoint was assessed by cardiac death or heart failure .

Results :

The plasma copeptin and NT - np levels in the terminal event group were significantly higher than those in the non - terminal event group ( P 0.05 ) . The area under the subject ' s working curve ( Receiver operating characteristic , ROCs ) was : copeptin0.602 ( SE , 0.052 ;
95 % CI 0.499 - 0.705 ) ;
NT-proBNP0.659(SE,0.048錛

本文編號：1743899