本文選題：燒傷 + 缺氧誘導(dǎo)因子-α　； 參考：《山東醫(yī)藥》2016年29期

【摘要】：缺氧誘導(dǎo)因子1α(HIF-1α)作為機(jī)體適應(yīng)氧環(huán)境變化的主要轉(zhuǎn)錄調(diào)節(jié)因子,參與了燒傷后血管通透性改變、腸黏膜屏障破壞、細(xì)胞凋亡、血管再生、細(xì)胞遷移等病理生理過(guò)程。HIF-1α能介導(dǎo)堿燒傷后角膜新生血管的形成,也能促進(jìn)燒傷創(chuàng)面的修復(fù)。HIF-1α還可通過(guò)基因治療,改善老年燒傷創(chuàng)面愈合延遲的缺陷。HIF-1α的這些作用很可能成為燒傷治療的新靶點(diǎn),但燒傷創(chuàng)面的惡劣微環(huán)境也為其干預(yù)治療提出了挑戰(zhàn)。
[Abstract]:Hypoxia-inducible factor-1 偽 (HIF-1 偽), as the main transcription regulatory factor, is involved in the changes of vascular permeability, intestinal mucosal barrier, apoptosis and vascular regeneration after burn.Cell migration and other pathophysiological processes. HIF-1 偽 can mediate corneal neovascularization after alkali burn, and promote the repair of burn wound. HIF-1 偽 can also be treated by gene therapy.These effects of HIF-1 偽 on the delayed healing of senile burn wounds are likely to be new targets for burn treatment, but the poor microenvironment of burn wounds also poses a challenge to the intervention of burn wounds.
【作者單位】： 西南醫(yī)科大學(xué)附屬醫(yī)院;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(31271049)
【分類號(hào)】：R644
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本文編號(hào)：1735709