本文選題：顱腦損傷　切入點：Tau蛋白　出處：《廣東醫(yī)學》2017年02期

【摘要】：目的通過檢測顱腦損傷(TBI)患者入院后不同時間段血清中的Tau蛋白濃度,對照比較TBI患者標準化治療后的預后情況。方法篩選無TBI及相關顱腦疾病的體檢者為對照組,檢測對照組血清中Tau蛋白的濃度。收集臨床確診的TBI患者76例,于傷后的6 h及1、3、7 d分別采集患者血清標本。通過ELISA法分別檢測對應時間段內(nèi)的血清Tau蛋白濃度。于患者入院標準化治療1個月后進行隨訪或復診計算患者預后分數(shù)(通過Barthel指數(shù)評分計算)。應用SPSS統(tǒng)計軟件對患者血清中Tau濃度、GCS評分、Barthel指數(shù)評分進行相關性分析。結果各TBI組血清Tau蛋白濃度與對照組相比較,差異有統(tǒng)計學意義(P0.05);重型組與輕中型組相比較,其血清Tau蛋白濃度差異有統(tǒng)計學意義(P0.05)。重型組患者的預后明顯差于輕中型組。預后不同的各組血清中Tau蛋白濃度相比較,預后差組、預后中組、預后良組與對照組差異有統(tǒng)計學意義(P0.05);預后差組與預后中組、預后良組差異有統(tǒng)計學意義(P0.05);預后中組與預后良組差異無統(tǒng)計學意義(P0.05)。結論在發(fā)生TBI后,患者血清中Tau蛋白含量升高,升高的程度與TBI的嚴重程度呈正相關。TBI的程度與患者預后有關,損傷越重,患者預后越差。預后差患者與患者血清中Tau蛋白含量相關,Tau蛋白含量極高者預后差。
[Abstract]:Objective to detect the concentration of Tau protein in serum of patients with craniocerebral injury (TBI) at different time after admission, and to compare the prognosis of patients with TBI after standardized treatment.Methods the control group was selected as the control group without TBI and related craniocerebral diseases. The concentration of Tau protein in serum of the control group was detected.The serum samples of 76 patients with TBI were collected at 6 hours and 3 days after injury.The concentration of serum Tau protein was detected by ELISA method.The prognostic scores (calculated by Barthel index score) were calculated 1 month after admission to standardized therapy.The correlation between Tau and Barthel index was analyzed by SPSS software.Results compared with the control group, the concentration of serum Tau protein in the TBI group was significantly different from that in the control group (P 0.05), and the serum Tau protein concentration in the severe group was significantly higher than that in the light group (P 0.05).The prognosis of severe group was significantly worse than that of light and medium group.There were significant differences in serum Tau protein concentration between groups with different prognosis, poor prognosis group, prognosis group, good prognosis group and control group (P 0.05), poor prognosis group and prognosis group.There was significant difference between the good group and the good group (P 0.05), but there was no significant difference between the group with good prognosis and the group with good prognosis (P 0.05).Conclusion after the onset of TBI, the serum Tau protein level increases, and the degree of elevation is positively correlated with the severity of TBI. The degree of TBI is related to the prognosis of the patients. The more serious the injury, the worse the prognosis of the patients.The prognosis of patients with poor prognosis and patients with extremely high Tau protein content was poor.
【作者單位】： 青海大學附屬醫(yī)院神經(jīng)外科;
【基金】：青海省科技廳項目(編號:9632016Y0203)
【分類號】：R651.15

【參考文獻】

相關期刊論文 前3條

1 趙子艾;周元國;;Tau蛋白過度磷酸化的致病機制及其在創(chuàng)傷性腦損傷中的作用[J];生理科學進展;2014年03期

2 李曉紅;陳，

本文編號：1714742