本文選題：膿毒癥　切入點(diǎn)：診斷　出處：《重慶醫(yī)學(xué)》2017年33期

【摘要】：目的探討外周血Th22在膿毒癥患者中的水平變化及其臨床意義。方法選取2014年4月至2017年4月在該院就診的膿毒癥患者180例為研究對象,根據(jù)病情嚴(yán)重程度將其分為普通膿毒癥組81例、嚴(yán)重膿毒癥組68例和膿毒癥休克組31例,另選取60例健康體檢者為對照。檢測各組外周血Th22、白細(xì)胞介素(IL)-22、IL-6及降鈣素原(PCT)水平,記錄急性生理與慢性健康狀況(APACHEⅡ)評分情況,采用受試者工作特征(ROC)曲線評估外周血Th22對膿毒癥早期診斷的價(jià)值。結(jié)果膿毒癥患者外周血Th22和IL-22水平明顯高于對照組(P0.05)。普通膿毒癥組、嚴(yán)重膿毒癥組及膿毒癥休克組患者外周血Th22、IL-22、APACHEⅡ評分及PCT水平比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。相關(guān)性分析顯示,外周血Th22與PCT、APACHEⅡ評分呈正相關(guān)(r=0.80、0.66,P0.01)。外周血Th22=1.9%時(shí),其敏感性和特異性分別為83.1%和85.2%,明顯優(yōu)于PCT。結(jié)論外周血Th22及其相關(guān)細(xì)胞因子對膿毒癥患者早期診斷及病情嚴(yán)重程度的評估具有重要的臨床價(jià)值。
[Abstract]:Objective to investigate the level of peripheral blood Th22 in patients with sepsis and its clinical significance.Methods 180 patients with sepsis from April 2014 to April 2017 were divided into general sepsis group (n = 81), severe sepsis group (n = 68) and septic shock group (n = 31).Another 60 healthy persons were selected as control.The levels of Th22, IL-6 and procalcitonin in peripheral blood of each group were measured, and the acute physiological and chronic health status (Apache 鈪，

本文編號：1702591