本文選題：骨髓　切入點：間質(zhì)干細(xì)胞移植　出處：《重慶醫(yī)學(xué)》2017年18期

【摘要】：目的探討干細(xì)胞移植對終末期肝病(ESLD)前后患者免疫、肝功能及相關(guān)指標(biāo)影響。方法選取鄭州大學(xué)附屬醫(yī)院南陽市中心醫(yī)院ESLD患者163例,隨機(jī)單盲取法分為2組,對照組81例給予常規(guī)、對癥治療,觀察組82例在對照組基礎(chǔ)上給予骨髓間充質(zhì)干細(xì)胞(BMSC)移植,觀察兩組治療前后免疫、肝功能及甲胎球蛋白(AFP)、凝血酶原活動率(PTA)、血漿總蛋白(TP)水平變化。結(jié)果觀察組治療后免疫功能指標(biāo)CD3~+、CD4~+、CD8~+、CD4~+/CD8~+比值、TP、PTA水平均高于同組治療前及對照組同期(P0.05),AFP、丙氨酸轉(zhuǎn)氨酶(ALT)、天冬氨酸轉(zhuǎn)氨酶(AST)、總膽紅素(TBIL)均低于同組治療前及對照組同期(P0.05)。兩組患者并發(fā)癥發(fā)生率比較,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論 BMSC移植治療ESLD,可改善患者免疫功能,提高肝功能,降低AFP水平。
[Abstract]:Objective to investigate the effect of stem cell transplantation on immunity, liver function and related indexes in patients with end-stage liver disease before and after ESLD. Methods 163 patients with ESLD in Nanyang Central Hospital, affiliated Hospital of Zhengzhou University, were randomly divided into two groups. 81 cases in the control group were treated with routine and symptomatic therapy, 82 cases in the observation group were transplanted with bone marrow mesenchymal stem cells (BMSC) on the basis of the control group, and the two groups were immunized before and after treatment. Results after treatment, the levels of immunological function index CD3 ~ + CD4 ~ + CD8 ~ + CD8 ~ + / CD8 ~ + and TPPTA in the observation group were higher than those in the same group and the control group before treatment and in the control group. The incidence of complications in the two groups was lower than that in the same group before treatment and in the control group (P 0.05), and the levels of alt, aspartate transaminase and total bilirubin TBILwere lower than those in the control group. Conclusion BMSC transplantation can improve the immune function, improve liver function and decrease the level of AFP in patients with ESLD.
【作者單位】： 鄭州大學(xué)附屬醫(yī)院南陽市中心醫(yī)院感染科;南陽醫(yī)學(xué)高等專科學(xué)�；A(chǔ)醫(yī)學(xué)部;
【基金】：河南省衛(wèi)生廳科研成果項目[宛科鑒字(2012)第103號99]
【分類號】：R575.3
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本文編號：1663737