本文關鍵詞：急性腦梗死患者血管內皮功能和同型半胱氨酸水平變化及其治療，由筆耕文化傳播整理發(fā)布。

急性腦梗死患者血管內皮功能和同型半胱氨酸水平變化及其治療

Vascular Endothelial Function and Homocysteine Level in Patients with Acute Cerebral Infarction and Its Treatment

[1] [2] [3] [4] [5] [6] [7] [8]

DENG Yuan - qiong, LIU Bo - sheng, DENG Yuan - qi, et al. Department of Functions, the Fourth Affiliated Hospital of Nan- chang University, Nanchang 330003, China

南昌大學第四附屬醫(yī)院功能科,江西省南昌市330003

文章摘要：目的觀察急性腦梗死患者血管內皮功能、同型半胱氨酸（Hey）水平變化，探討葉酸、維生素B12的治療作用。方法選擇我院2011年1月-2012年10月收治的急性腦梗死患者160例，按是否合并高血壓分為腦梗死合并高血壓組80例和腦梗死未合并高血壓組80例，再采用隨機數(shù)字表將腦梗死未合并高血壓組80例患者分為干預I組和非干預I組，每組40例；將腦梗死合并高血壓組80例患者分為干預Ⅱ組和非干預Ⅱ組，每組40例；選擇同期在我院健康體檢中心體檢健康者80例為對照組。采用彩色超聲診斷儀測定肱動脈內徑及頸動脈內膜中層厚度（IMT），計算反應性充血后血管內徑變化率（FMD）；循環(huán)酶法測定血清同型半胱氨酸（Hey）水平；硝酸還原酶法測定血清一氧化氮（NO）水平、酶聯(lián)免疫吸附試驗（ELISA）測定血清內皮型NO合成酶（eNOS）水平。采用美國國立衛(wèi)生研究院卒中量表（NIHSS）評價干預組治療前后神經功能缺損程度，，采用Barthel指數(shù)（BI）評價干預組治療前后日常生活能力。結果腦梗死合并高血壓組和腦梗死未合并高血壓組FMD及血清NO、eNOS水平低于對照組（P〈0．01），且腦梗死合并高血壓組低于腦梗死未合并高血壓組（P〈0．01）；腦梗死合并高血壓組和腦梗死未合并高血壓組IMT及血清Hey水平高于對照組（P〈0．01），且腦梗死合并高血壓組高于腦梗死未合并高血壓組（P〈0．01）。干預I組治療2周后BI評分及血清NO、eNOS水平高于非干預I組，NIHSS評分低于非干預I組（P〈0．01）；干預I組治療12周后BI評分及血清NO、eNOS水平高于非干預I組，NIHSS評分及血清Hey水平低于非干預I組（P〈0．01）。干預Ⅱ組治療2周后、治療12周后BI評分及血清NO、eNOS水平高于非干預Ⅱ組，NIHSS評分及血清Hey水平低于非干預Ⅱ組（P〈0．01）。Spearman等級相關性分析結果顯示，腦梗?

Abstr：Objective To evaluate the vascular endothelial function and homocysteine （Hcy） level in patients with actue cerebral infarction, and explore the effects of folic acid, Vitamin B12 on the prognosis of acute cerebral infarction. Meth- otis A total of 160 patients with acute cerebral infarction treated in our hospital from January 2011 to October 2012 were included in this study. The patients were divided into two groups based on their blood pressure, namely the Group I of 80 patients with normal blood pressure and Group II of 80 patients with hypertension. Each group was divided randomly into two subgroups of 40 patients, namely Group I with intervention, Group I without intervention, Group lI with intervention, and Group 11 without intervention. And 80 healthy people who came to our hospital for regular physical examination during the same period were recrui- ted as the control group. The inner diameter of brachial artery, carotid intima- media thickness （IMT） were detected by Color Doppler, and brachial artery flow -mediated dilation （FMD） calculated; Serum Hcy level was determined by enzymatic cycling assay, serum nitrogen oxide （NO） by nitrate reductase method, and the serum level of endothelial nitrogen oxide synthase （eNOS） was measured by enzyme -linked immunosorbent assay （ELISA）. The degree of neurological deficits was evaluated by the National Institutes of Health Stroke Scale （NIHSS） of the U. S. , and the ability of daily living was rated with Barthel Index （BI）. Results The FMD, levels of NO, eNOS were lower in Group I with hypertension than those in Group H with normal blood pressure, all of which were lower than those in control group. The levels of Hcy and IMT were higher in Group

文章關鍵詞：

Keyword：:Brain infarction Endothelialium vascular Cysteine Folic acid Vitamin B12

課題項目：江西省科技計劃項目（20122BBG70146）

作者信息：會員可見

  本文關鍵詞：急性腦梗死患者血管內皮功能和同型半胱氨酸水平變化及其治療，由筆耕文化傳播整理發(fā)布。