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  本文選題：臭氧　切入點：急性期腦梗塞　出處：《遼寧中醫(yī)藥大學》2013年碩士論文　論文類型：學位論文

【摘要】：目的：驗證臭氧對急性期腦梗塞治療作用，并驗證內皮素是與臨床療效一致的化驗指標，且其數(shù)值可反映急性期腦梗塞的患者病情的輕重，并對其作以分析探討。 方法：將于我院救治的急性腦梗塞的患者120例隨機分成兩組，非臭氧治療對照組30例，臭氧等綜合治療組90例，對照組行西醫(yī)吸氧、脫水、抗血小板等常規(guī)治療，治療組于如上西醫(yī)常規(guī)治療的基礎上，行臭氧治療，兩組療程均為14天，并監(jiān)測患者血漿ET水平（住院第1，7,14天），以及進行相關療效評判，并對記錄之結果行統(tǒng)計學分析。 結果： 1臨床表現(xiàn) 治療組與對照組比，神經(jīng)功能缺損評分明顯降低，，證實治療組神經(jīng)功能恢復良好，優(yōu)于對照組。另外，患者經(jīng)治療后，半身不遂或單臂單腿不遂或口眼歪斜或舌強言蹇或不語，頭暈目眩、偏身麻木、局部刺痛，等癥狀較前緩解，治療組更為明顯。 2理化檢查 治療組在常規(guī)治療基礎上加用臭氧可以使患者急性期內(治療后7d)ET明顯下降，且具有統(tǒng)計學意義。兩組組內ET的動態(tài)演變和本組內各期的神經(jīng)功能缺損，評分量表積分變化呈高度正相關，提示檢測ET，觀察其動態(tài)演變在一定程度上可反應患者神經(jīng)功能改善和神經(jīng)保護作用。 另外，腦梗塞輕度患者ET高于正常組，中重度患者兩指標顯著高于輕度患者，且呈正相關。提示ET不僅參于腦梗塞病理過程，而且與病情程度呈正相關。且臨床治療有效率高于對照組，提示ET反映了不同程度腦梗塞患者的治療效果。 3整體療效 治療后，按照療效判定標準，行療效評判，其中，對照組基本治愈1例，顯著進步5例，進步13例，無效11例，總有效率63.33%，治療組基本治愈5例，顯著進步39例，進步29例，無效17例，總有效率81.11%，經(jīng)統(tǒng)計分析證實，治療組西醫(yī)臨床療效較對照組更佳，治療組的總有效率高達81.11%。 結論： 采用臭氧治療對急性期腦梗塞的臨床療效滿意，內皮素是與腦梗塞的臨床療效一致的化驗指標，且其數(shù)值標志著患者病情輕重。
[Abstract]:Objective: to verify the therapeutic effect of ozone on acute cerebral infarction, and to verify that endothelin is an index consistent with clinical efficacy, and its value can reflect the severity of patients with acute cerebral infarction. Methods: 120 patients with acute cerebral infarction who were treated in our hospital were randomly divided into two groups: the control group (n = 30), the control group (n = 90), and the control group (n = 90) received routine western medicine therapy, such as oxygen inhalation, dehydration, anti-platelet therapy, etc. The treatment group was treated with ozone on the basis of routine western medicine treatment. The two groups were treated with ozone for 14 days, and the plasma et level was monitored (1 ~ 7 ~ 14 days after hospitalization), and the related curative effect was evaluated, and the recorded results were analyzed statistically. Results:. 1 Clinical manifestations. Compared with the control group, the neurological deficit score of the treatment group was significantly decreased, which proved that the nerve function of the treatment group recovered well and was superior to that of the control group. The symptoms of hemiplegia or one-arm one-leg failure or mouth and eye askew or tongue strong speech or muzzle, dizziness, partial numbness, local stinging pain, and so on were relieved, and the treatment group was more obvious. 2 physical and chemical examination. In the treatment group, the level of et decreased significantly in the acute phase (7 days after treatment) and had statistical significance. The dynamic evolution of et in the two groups and the nerve function defect in each stage of the treatment group were observed. There was a highly positive correlation between the scores and the scores, which suggested that the detection of ETs and the dynamic evolution of ETs could reflect the improvement of neurologic function and the neuroprotective effect of the patients to a certain extent. In addition, et in mild patients with cerebral infarction was higher than that in normal patients, and the two indexes in moderate and severe patients were significantly higher than those in mild patients, which indicated that et was not only involved in the pathological process of cerebral infarction, but also in the pathological process of cerebral infarction. The effective rate of clinical treatment was higher than that of the control group, suggesting that et reflected the therapeutic effect of patients with different degrees of cerebral infarction. 3 overall curative effect. After treatment, according to the criterion of curative effect, the curative effect was evaluated. In the control group, 1 case was basically cured, 5 cases were significantly improved, 13 cases were improved, 11 cases were ineffective, and the total effective rate was 63.33%. In the treatment group, 5 cases were basically cured, 39 cases were improved significantly, 29 cases were improved. 17 cases were ineffective and the total effective rate was 81.11%. The clinical efficacy of western medicine in the treatment group was better than that in the control group, and the total effective rate in the treatment group was as high as 81.11%. Conclusion:. Ozone therapy was used to treat acute cerebral infarction with satisfactory clinical effect. Endothelin is the same test index as the clinical efficacy of cerebral infarction and its value indicates the severity of the patient's condition.
【學位授予單位】：遼寧中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R743.33

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