發(fā)布時(shí)間：2018-03-03 10:33

  本文選題：垂體后葉注射液　切入點(diǎn)：注射用烏司他丁　出處：《中國(guó)藥房》2017年17期 　論文類(lèi)型：期刊論文

【摘要】：目的:探討垂體后葉注射液聯(lián)合注射用烏司他丁治療嚴(yán)重肺挫傷的療效和安全性。方法:采用回顧性研究方法,選擇我院2015年1月-2016年5月收治的嚴(yán)重肺挫傷患者60例,按照治療方案分為對(duì)照組和觀察組,各30例。對(duì)照組患者給予注射用烏司他丁10萬(wàn)U加至0.9%氯化鈉注射液100mL中靜脈滴注,bid;觀察組患者在對(duì)照組基礎(chǔ)上給予垂體后葉注射液6U加至0.9%氯化鈉注射液49mL中靜脈泵注(初始速率為0.008U/min,之后調(diào)整為≤0.04U/min),bid。兩組患者均治療1周。觀察兩組患者治療前后的呼吸頻率、肺挫傷簡(jiǎn)易評(píng)分、X線(xiàn)胸片評(píng)分、動(dòng)脈血?dú)庵笜?biāo)[氧分壓(PaO_2)、二氧化碳分壓(PaCO_2)、血氧飽和度(SaO_2)和氧合指數(shù)(PO_2/FiO_2)]、炎癥指標(biāo)[白細(xì)胞介素2(IL-2)、IL-6、IL-10、超敏C反應(yīng)蛋白(hs-CRP)、腫瘤壞死因子α(TNF-α)]水平及臨床療效,并記錄不良反應(yīng)發(fā)生情況。結(jié)果:治療前,兩組患者呼吸頻率、肺挫傷簡(jiǎn)易評(píng)分、X線(xiàn)胸片評(píng)分、動(dòng)脈血?dú)庵笜?biāo)、炎癥指標(biāo)水平比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組患者呼吸頻率、肺挫傷簡(jiǎn)易評(píng)分、X線(xiàn)胸片評(píng)分和IL-6、hs-CRP、TNF-α水平均降低,且觀察組明顯低于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05);兩組患者PaO_2、PaCO_2、SaO_2、PO_2/FiO_2、IL-2、IL-10水平均明顯升高,且觀察組明顯高于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。觀察組臨床總有效率(100%)明顯高于對(duì)照組(86.67%),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。對(duì)照組患者的不良反應(yīng)發(fā)生率(13.33%)明顯高于觀察組(6.67%),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:垂體后葉注射液聯(lián)合注射用烏司他丁對(duì)嚴(yán)重肺挫傷患者療效較好,并能有效抑制機(jī)體炎癥反應(yīng),且安全性較高。
[Abstract]:Objective: to investigate the efficacy and safety of posterior pituitary injection combined with ulinastatin injection in the treatment of severe pulmonary contusion. Methods: a retrospective study was conducted in 60 patients with severe pulmonary contusion from January 2015 to May 2016 in our hospital. According to the treatment plan, they were divided into two groups: control group and observation group. 30 cases each. The patients in the control group were given urinastatin 100,000 U for injection to 0.9% mL sodium chloride injection by intravenous drip, while the patients in the observation group were given 6 U injection of posterior pituitary lobe injection to 49 mL 0.9% sodium chloride injection on the basis of the control group. Intravenous infusion (initial rate 0.008 U / min, then adjusted to 鈮，

本文編號(hào)：1560664