本文選題：急性百草枯中毒　切入點(diǎn)：降鈣素原　出處：《山東醫(yī)藥》2017年29期 　論文類(lèi)型：期刊論文

【摘要】：目的探討外周血降鈣素原(PCT)水平檢測(cè)對(duì)急性百草枯中毒患者預(yù)后的預(yù)測(cè)價(jià)值。方法急性百草枯中毒患者89例,根據(jù)患者中毒后1個(gè)月的預(yù)后狀況分為生存組(59例)和死亡組(30例),比較生存組和死亡組患者的口服百草枯劑量、口服百草枯濃度、PCT、C反應(yīng)蛋白(CRP)、白細(xì)胞(WBC)和丙氨酸氨基轉(zhuǎn)移酶(ALT)差異,并利用Pearson相關(guān)性分析PCT水平與上述各指標(biāo)的關(guān)系,ROC曲線評(píng)析PCT水平預(yù)測(cè)1個(gè)月內(nèi)死亡事件發(fā)生的價(jià)值。結(jié)果與生存組相比,死亡組口服百草枯劑量、口服百草枯濃度、PCT、CRP、WBC和ALT均高(P均0.05)。外周血PCT水平與CRP、WBC、ALT、口服百草枯劑量和口服百草枯濃度存在正相關(guān)(P均0.05);ROC曲線結(jié)果顯示:當(dāng)PCT≥0.90μg/L時(shí),判斷急性百草枯中毒患者1個(gè)月內(nèi)死亡事件發(fā)生的靈敏度為90.00%,特異度為50.85%,曲線下面積為0.74,95%CI為0.64~0.85。結(jié)論外周血PCT水平檢測(cè)對(duì)急性百草枯患者的預(yù)后有良好預(yù)測(cè)價(jià)值。
[Abstract]:Objective to study the prognostic value of serum procalcitonin (PCT) level in patients with acute paraquat poisoning. Methods 89 patients with acute paraquat poisoning were included in this study. According to the prognosis of one month after poisoning, the patients were divided into survival group (59 cases) and death group (30 cases). The difference of oral paraquat concentration (PCT) C-reactive protein (CRP), WBC) and alanine aminotransferase (alt) was observed. Pearson correlation analysis was used to analyze the relationship between PCT level and the above indexes. The value of PCT level in predicting the occurrence of death events within one month was evaluated. Results compared with the survival group, the oral paraquat dose in the dead group was higher than that in the control group. The levels of PCT in peripheral blood were significantly higher than those in the control group (P < 0.05). There was a positive correlation between the dose of paraquat and the concentration of paraquat by oral administration. The results showed that when PCT 鈮，

本文編號(hào)：1556403