本文關鍵詞： 艾司西酞普蘭 奧扎格雷鈉 急性腦梗死 焦慮抑郁　出處：《中國藥房》2016年26期 　論文類型：期刊論文

【摘要】：目的:觀察艾司西酞普蘭聯(lián)合奧扎格雷鈉治療老年急性腦梗死合并焦慮抑郁障礙患者的臨床療效及安全性。方法:選擇老年急性腦梗死合并焦慮抑郁障礙患者140例,按隨機數(shù)表法分為對照組和觀察組,各70例。對照組患者采用常規(guī)治療,并給予注射用奧扎格雷鈉40~80 mg加入0.9%氯化鈉注射500 ml中,ivgtt,bid;觀察組患者在對照組基礎上加服草酸艾司西酞普蘭片10 mg,qd。兩組患者均治療8周。比較兩組患者治療前后漢密爾頓焦慮量表(HAMA)、漢密爾頓抑郁量表(HAMD)、美國國立衛(wèi)生院腦卒中量表(NIHSS)評分及Barthel(BI)指數(shù),并觀察臨床療效及不良反應發(fā)生情況。結果:兩組患者治療前HAMA、HAMD、NIHSS、BI指數(shù)及治療1周后NIHSS、BI指數(shù)比較,差異均無統(tǒng)計學意義(P0.05);觀察組患者治療1、4、8周后HAMA、HAMD評分及治療4、8周后NIHSS、BI指數(shù)顯著改善,對照組患者治療4、8周后上述指標顯著改善,且觀察組改善程度顯著優(yōu)于對照組,差異均有統(tǒng)計學意義(P0.05)。觀察組患者臨床總有效率為87.14%,顯著高于對照組的74.29%,差異有統(tǒng)計學意義(P0.05)。兩組患者不良反應發(fā)生率比較,差異無統(tǒng)計學意義(P0.05)。結論:艾司西酞普蘭聯(lián)合奧扎格雷鈉治療老年急性腦梗死合并焦慮抑郁障礙患者的療效顯著,能明顯改善患者的焦慮抑郁狀態(tài)和神經功能,且安全性較好。
[Abstract]:Objective: to observe the clinical efficacy and safety of Escitalopram combined with ozagrel sodium in the treatment of elderly patients with acute cerebral infarction complicated with anxiety and depression. Methods: 140 elderly patients with acute cerebral infarction complicated with anxiety and depression were selected. The patients in the control group were divided into two groups, the control group and the observation group with 70 cases each. The patients in the control group were treated with routine therapy. Ozagrel sodium 4080mg plus 0.9% sodium chloride was injected into 500ml iv gttbidin. The patients in the observation group were treated with 10 mg estalopram oxalate on the basis of the control group. The two groups were treated for 8 weeks. The two groups were compared before and after treatment. Hamilton anxiety scale (Hamilton anxiety scale), Hamilton Depression scale (Hamd), National Institutes of Health (NHS) Stroke scale (NIHSS) and Barthelberg Index (BI); The clinical efficacy and adverse reactions were observed. Results: the index of HAMA-HAMD-NIHSSBI before treatment and the index of NIHSSBI after one week of treatment were compared between the two groups. The scores of Hama Hamd and NIHSSBI index in the observation group were significantly improved after 48 weeks of treatment, and those in the control group were significantly improved after 48 weeks of treatment, and the degree of improvement in the observation group was significantly better than that in the control group. The total clinical effective rate in the observation group was 87.14, which was significantly higher than that in the control group (74.29), and the difference was statistically significant (P 0.05). Conclusion: the efficacy of Escitalopram combined with ozagrel sodium in the treatment of elderly patients with acute cerebral infarction combined with anxiety and depression disorder is significant, and it can obviously improve the anxiety and depression state and neurological function of the patients, and the safety is good.
【作者單位】： 武漢市普仁醫(yī)院神經內科;
【分類號】：R971

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