本文關(guān)鍵詞： 阿托伐他汀 高血壓 ST段抬高 心肌梗死 Lp-PLA　出處：《重慶醫(yī)學(xué)》2016年36期 　論文類型：期刊論文

【摘要】：目的探討阿托伐他汀強(qiáng)化療法對(duì)高血壓并發(fā)ST段抬高急性心肌梗死患者心臟功能與脂蛋白磷脂酶A2(LpPLA2)的影響。方法選取2014年6月至2016年4月該院收治的高血壓并發(fā)ST段抬高急性心肌梗死患者78例,依據(jù)隨機(jī)數(shù)表法分為觀察組(阿托伐他汀強(qiáng)化療法)和對(duì)照組(常規(guī)治療),比較兩組患者治療前后的血壓、血脂、Lp-PLA2、心功能變化。結(jié)果治療前,兩組患者的血壓、血脂指標(biāo)差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療后,兩組患者的收縮壓(SBP)、舒張壓(DBP)、低密度脂蛋白膽固醇(LDL-C)明顯降低,高密度脂蛋白膽固醇(HDL-C)顯著升高,且觀察組患者的SBP、HDL-C、LDL-C與對(duì)照組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療前,兩組患者的Lp-PLA2差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療后,兩組患者的Lp-PLA2均明顯降低,且觀察組變化幅度更大(P0.05)。治療前,兩組患者的心功能指標(biāo)差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療后,觀察組患者的左室舒張末期內(nèi)徑(LVEDD)、左室收縮末期內(nèi)徑(LVESD)明顯降低,左室射血分?jǐn)?shù)(LVEF)、一氧化碳(CO)、心臟指數(shù)(CI)顯著升高,與對(duì)照組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論阿托伐他汀強(qiáng)化療法能夠明顯降低高血壓并發(fā)ST段抬高急性心肌梗死患者血壓及Lp-PLA2水平,改善患者心臟功能,值得臨床推廣。
[Abstract]:Objective to investigate the effects of Atto vastatin intensive therapy on cardiac function and lipoprotein phospholipase A _ 2 (LpPLA _ 2) in patients with hypertension complicated with ST-segment elevation acute myocardial infarction (St segment elevation). Methods from June 2014 to April 2016, 78 patients with hypertension complicated with ST-segment elevation acute myocardial infarction were selected. According to the random table method, the patients were divided into two groups: observation group (Atto vastatin intensive therapy) and control group (routine treatment). The blood pressure, blood lipid and Lp-PLA2 were compared between the two groups before and after treatment. Results there was no significant difference in blood pressure and blood lipids between the two groups before treatment. After treatment, the systolic blood pressure (SBP), diastolic blood pressure (DBP), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were significantly decreased in both groups. Compared with the control group, there was a significant difference between the observation group and the control group (P 0.05) before treatment. There was no significant difference in Lp-PLA2 between the two groups (P 0.05). After treatment, the Lp-PLA2 of the two groups was significantly decreased, and the change of the observation group was greater than that of the control group (P 0.05). Before treatment, there was no significant difference in cardiac function between the two groups (P 0.05). After treatment, left ventricular end-diastolic diameter (LVEDDN) and left ventricular end-systolic diameter (LVESD) were significantly decreased, left ventricular ejection fraction (LVEF) and carbon monoxide (CO) were significantly decreased in the observation group. Cardiac index (CI) increased significantly. Conclusion Atto vastatin intensive therapy can significantly reduce blood pressure and Lp-PLA2 levels in patients with hypertension complicated with ST-segment elevation acute myocardial infarction. Improving the heart function of patients is worth popularizing in clinic.
【作者單位】： 鄭州大學(xué)附屬醫(yī)院南陽市中心醫(yī)院西藥科;
【分類號(hào)】：R542.22;R544.1

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