【摘要】：目的客觀(guān)量化鵪鶉尿酸(UA)、糞尿及舌象等指標(biāo),探討高尿酸血癥鵪鶉模型的中醫(yī)證候分型,為鵪鶉證候模型評(píng)價(jià)研究提供參考。方法采用高嘌呤飲食誘導(dǎo)鵪鶉高尿酸血癥模型,動(dòng)態(tài)觀(guān)察鵪鶉尿酸水平、糞尿性狀及舌象并進(jìn)行數(shù)字化定量分析。運(yùn)用健脾利濕中藥菊苣進(jìn)行反證,從"四診"及以藥測(cè)證兩個(gè)角度探討高尿酸血癥鵪鶉中醫(yī)證候類(lèi)型。結(jié)果問(wèn)診、聞診及望診顯示,實(shí)驗(yàn)第17、30天模型組鵪鶉糞尿濕重有升高趨勢(shì),糞尿較溏稀氣味較大,正常組鵪鶉舌色以紅色調(diào)為主,模型組鵪鶉舌色變淡呈淡白舌;第22、32天舌象紅色度(red intensity,r)及紅色面積比例顯著下降;與正常組比,第14、21天血清尿酸水平顯著升高(P0.05)。與模型組比,菊苣組糞尿濕重、干重顯著升高(P0.05);r及紅色面積比例顯著上升(P0.05);第21天菊苣組尿酸水平顯著降低(P0.05)。結(jié)論采用高嘌呤飲食誘導(dǎo)法,可成功誘導(dǎo)鵪鶉高尿酸血癥。量化"四診"指標(biāo)及以藥測(cè)證研究提示:鵪鶉模型部分病理改變與飲食不節(jié)導(dǎo)致的"脾虛痰濕"證候有一定的相似之處。
[Abstract]:Objective to study the TCM syndromes of quail model with hyperuricemia by objectively quantifying the indexes of (UA), fecal urine and tongue, and to provide reference for the evaluation of quail syndrome model. Methods the hyperuricemia model of quail was induced by hyperpurine diet. The syndrome types of hyperuricemia quail were discussed from the two angles of "four diagnosis" and "drug test" by using invigorating spleen and dampness traditional Chinese medicine chicory. Results the results showed that the wet weight of quail feces and urine in the model group increased on the 17th day of the experiment, the smell of feces and urine was larger than that of loose stool, the color of the tongue of the normal group was mainly red, and the color of the model group was light and white. On the 22nd day, the red intensity,r and the ratio of red area decreased significantly, and the serum uric acid level increased significantly at day 1421 compared with the normal group (P0.05). Compared with the model group, the feces and urine wet weight and dry weight of chicory group increased significantly (P0.05); r and red area ratio significantly increased (P0.05); on the 21st day, the uric acid level of chicory group decreased significantly (P0.05). Conclusion hyperuricemia can be induced successfully by hyperpurine diet. The study of quantifying the index of "four diagnoses" and examining the syndrome by medicine indicated that there were certain similarities between the pathological changes of quail model and the syndrome of "spleen deficiency and phlegm dampness" caused by diet.
【作者單位】： 北京中醫(yī)藥大學(xué);
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(No.81073068,81274153) 北京中醫(yī)藥大學(xué)研究生自主立項(xiàng)課題(No.2011-JYBZZ-XS067) 北京中醫(yī)藥大學(xué)科研創(chuàng)新團(tuán)隊(duì)項(xiàng)目(No.2011-CXTD-14)
【分類(lèi)號(hào)】：R-332

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