51例帶狀皰疹生活質(zhì)量研究
發(fā)布時(shí)間:2021-08-27 21:16
帶狀皰疹(HZ)是由潛伏在感覺(jué)背根或顱神經(jīng)節(jié)中的水痘-帶狀皰疹病毒(VZV)再激活所致,通常表現(xiàn)為沿著皮膚神經(jīng)分布的疼痛性水皰疹。HZ的發(fā)病率和嚴(yán)重程度隨年齡增長(zhǎng)而增加,50歲后顯著增加。在總?cè)丝谥?年齡調(diào)整后的HZ發(fā)病率為3.4-5.0/1000人-年,65.9歲以上的人群為8-11/1000人-年。通常臨床表現(xiàn)足以懷疑診斷,而Tzanck涂片可以迅速證實(shí)臨床懷疑。帶狀皰疹患者的生活質(zhì)量(QoL)可因與病情相關(guān)的急性疼痛和PHN的長(zhǎng)期、潛在的衰弱疼痛而大大降低。橫斷面流行病學(xué)研究表明,HZ引起的疼痛和不適對(duì)患者的生活質(zhì)量(QoL)和參與日;顒(dòng)的能力有顯著的負(fù)面影響。到目前為止,我國(guó)僅有50篇關(guān)于HZ流行病學(xué)和負(fù)擔(dān)的文章被引用,而且很少有關(guān)于帶狀皰疹生活質(zhì)量(ZQOL)的研究。為了解決這一問(wèn)題,ZQOL研究旨在評(píng)估患者報(bào)告的蚌埠地區(qū)(蚌埠醫(yī)學(xué)院第一附屬醫(yī)院)HZ對(duì)QOL的影響和患者對(duì)藥物治療的滿意度。目的:評(píng)價(jià)HZ管理的有效性。方法:采用橫斷面觀察設(shè)計(jì),于2018年4月至2019年2月在蚌埠醫(yī)學(xué)院第一附屬醫(yī)院皮膚科進(jìn)行為期10個(gè)月的研究。符合條件的患者為年齡40歲及以上,且有可見(jiàn)的H...
【文章來(lái)源】:蚌埠醫(yī)學(xué)院安徽省
【文章頁(yè)數(shù)】:80 頁(yè)
【學(xué)位級(jí)別】:碩士
【文章目錄】:
ABBREVIATIONS
ABSTRACT
中文摘要
Ⅰ- INTRODUCTION
Ⅱ- CONTENT AND EXPLANATION
Ⅲ- RESEARCH QUESTION
Ⅳ- AIM AND OBJECTIVES
1. Study aim
2. Objectives
Ⅴ- LITTERATURE REVIEW
1. Definition
2. Epidemiology
3. Pathophysiology
4. Clinical features
5. Zoster-associated pain (post herpetic neuralgia)
6. Diagnosis
7. Quality of life
8. Treatment
8.1. Antiviral therapy
8.2. Corticosteroids
8.3. Analgesics
8.4. Opioids
8.5. Tricyclic antidepressants
8.6. Topical therapy
8.7. Other treatments
9. Prevention
Ⅵ- METHODS
1. Study overview
2. Study design
3. Study population
4. Study schedule
5. Questionnaires
6. Statistical analysis
Ⅶ- RESULTS
1. Socio-demographic parameters
2. Details of medical care and treatment
3. Zoster quality of life
3.1. Zoster Brief Pain Inventory
3.2. Quality of life
3.2.1. EuroQol-5Dimension-3 Level
3.2.2. MOS 36 Short-Form Health Survey
3.2.3. Treatment Satisfaction Questionnaire for Medication
Ⅷ- DISCUSSION
1. Limitations of the study
2. Socio-demographic parameters
3. Zoster brief pain inventory and zoster quality of life
Ⅸ- CONCLUSION
REFERENCES
APPENDICE
本文編號(hào):3367102
【文章來(lái)源】:蚌埠醫(yī)學(xué)院安徽省
【文章頁(yè)數(shù)】:80 頁(yè)
【學(xué)位級(jí)別】:碩士
【文章目錄】:
ABBREVIATIONS
ABSTRACT
中文摘要
Ⅰ- INTRODUCTION
Ⅱ- CONTENT AND EXPLANATION
Ⅲ- RESEARCH QUESTION
Ⅳ- AIM AND OBJECTIVES
1. Study aim
2. Objectives
Ⅴ- LITTERATURE REVIEW
1. Definition
2. Epidemiology
3. Pathophysiology
4. Clinical features
5. Zoster-associated pain (post herpetic neuralgia)
6. Diagnosis
7. Quality of life
8. Treatment
8.1. Antiviral therapy
8.2. Corticosteroids
8.3. Analgesics
8.4. Opioids
8.5. Tricyclic antidepressants
8.6. Topical therapy
8.7. Other treatments
9. Prevention
Ⅵ- METHODS
1. Study overview
2. Study design
3. Study population
4. Study schedule
5. Questionnaires
6. Statistical analysis
Ⅶ- RESULTS
1. Socio-demographic parameters
2. Details of medical care and treatment
3. Zoster quality of life
3.1. Zoster Brief Pain Inventory
3.2. Quality of life
3.2.1. EuroQol-5Dimension-3 Level
3.2.2. MOS 36 Short-Form Health Survey
3.2.3. Treatment Satisfaction Questionnaire for Medication
Ⅷ- DISCUSSION
1. Limitations of the study
2. Socio-demographic parameters
3. Zoster brief pain inventory and zoster quality of life
Ⅸ- CONCLUSION
REFERENCES
APPENDICE
本文編號(hào):3367102
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