Viral protein R（Vpr） plays an important role in the replication and pathogenesis of Human immunodeficiency virus type 1（HIV-1）. Some of the various functions attributed to Vpr, including the induction of G2/M cell cycle arrest, activating the NF-κB pathway, and promoting viral reverse transcription, might be interrelated. To test this hypothesis, a panel of Vpr mutants were investigated for their ability to induce G2/M arrest and to activate the NF-κB pathway. The results showed that the Vpr mut... 

【文章來(lái)源】：Virologica Sinica. 2015,30(06)

【文章頁(yè)數(shù)】：8 頁(yè)

【文章目錄】：
INTRODUCTION
MATERIALS AND METHODS
    Plasmids
    Cell culture and transfection
    RNA interference
    Cell cycle analysis
    Luciferase assay
RESULTS
    NF-κB activation and G2/M arrest induced by Vpr mutants
    Activation of the NF-κB pathway promotes Vprinduced cell cycle arrest
DISCUSSION
COMPLIANCE WITH ETHICS GUIDELINES
AUTHOR CONTRIBUTIONS



本文編號(hào)：2970401