【摘要】：目的分析高效抗反轉(zhuǎn)錄病毒治療(HAART)過(guò)程中影響免疫功能重建的因素。方法 2003年9月至2013年6月,采用回顧式隊(duì)列分析,從國(guó)家艾滋病抗病毒治療數(shù)據(jù)庫(kù)中篩選出按要求完成隨訪的病人5567例,檢測(cè)病人基線及HAART治療9-15個(gè)月后的CD+4T淋巴細(xì)胞(簡(jiǎn)稱CD4細(xì)胞)數(shù)量,將CD4細(xì)胞200個(gè)/μL或較基線增長(zhǎng)20%定義為免疫重建不良,采用Logistic回歸分析觀察其影響因素。結(jié)果 HAART有效率為54.25%,共有2547例病人發(fā)生免疫重建不良,男性[比值比(OR):1.58,95%可信區(qū)間(CI):(1.41~1.76)]、高齡[~60歲OR:2.25,95%CI:(1.38~3.67)]、60歲OR:2.57,95%CI:(1.54~4.31)]、靜脈吸毒、基線CD4細(xì)胞水平過(guò)低、合并丙型肝炎病毒(HCV)[OR:1.68,95%CI(1.26~2.24)]感染、結(jié)核菌(TB)感染、病毒抑制不良[5000拷貝OR:4.05,95%CI:(2.82~5.82)]等,均是發(fā)生免疫重建不良的危險(xiǎn)因素,而乙型肝炎病毒表面抗原(HBsAg)陽(yáng)性未發(fā)現(xiàn)與免疫重建相關(guān)[OR:0.90,95%CI:(0.71~1.16)]。結(jié)論男性、高齡、靜脈吸毒、基線CD4細(xì)胞水平過(guò)低、合并HCV感染、病毒抑制不良等,均是發(fā)生免疫重建不良的危險(xiǎn)因素,臨床上需引起注意。
[Abstract]:Objective to analyze the factors affecting immune function reconstruction in the process of highly effective antiretrovirus therapy for (HAART). Methods from September 2003 to June 2013, 5567 patients who completed follow-up according to the requirements were selected from the national AIDS antiviral treatment database. The number of CD 4T lymphocytes (CD4 cells) at baseline and after 9 to 15 months of HAART treatment was measured. The number of CD4 cells 200 / 渭 L or 20% more than the base line was defined as poor immune reconstruction. Logistic regression analysis was used to observe the influencing factors. Results the effective rate of HAART was 54.25%. A total of 2547 patients had poor immune reconstruction, male [ratio 1.58, 95% confidence interval (CI): (1.41 鹵1.76)], advanced age [60 years old OR:2.25,95%CI: (1.38 鈮，

本文編號(hào)：2498304