γ-干擾素釋放試驗(yàn)在肺外結(jié)核診斷中的應(yīng)用與評(píng)價(jià)
發(fā)布時(shí)間：2019-05-23 05:15
【摘要】：目的探討γ-干擾素釋放試驗(yàn)(T細(xì)胞斑點(diǎn)試驗(yàn))在肺外結(jié)核診斷中的使用效能。方法通過對(duì)265例入組的肺外結(jié)核疑似患者進(jìn)行T細(xì)胞斑點(diǎn)試驗(yàn)檢測(cè),分析該技術(shù)在肺外結(jié)核中的診斷效能和影響該檢測(cè)結(jié)果的風(fēng)險(xiǎn)因素。結(jié)果 265例患者中,確診肺外結(jié)核147例、可疑肺外結(jié)核32例、排除結(jié)核感染86例。在去除可疑樣本之后,T細(xì)胞斑點(diǎn)試驗(yàn)靈敏度和特異性分別為81%和53%。其中,T細(xì)胞斑點(diǎn)試驗(yàn)對(duì)淋巴結(jié)核與結(jié)核性腹膜炎檢測(cè)靈敏度最高,均為88%;結(jié)核性胸膜炎檢測(cè)的靈敏度最低,為75%;T細(xì)胞斑點(diǎn)試驗(yàn)對(duì)淋巴結(jié)核檢測(cè)的特異性最高,為67%;而腸結(jié)核檢測(cè)的特異性最低,僅為44%。在免疫功能低下人群中,其靈敏度較免疫功能正常人群顯著降低(P0.05)。此外,年齡(≥65歲)對(duì)T細(xì)胞斑點(diǎn)試驗(yàn)靈敏度及對(duì)陽(yáng)性預(yù)測(cè)值和陰性預(yù)測(cè)值的影響具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 T細(xì)胞斑點(diǎn)試驗(yàn)?zāi)軌蜃鳛橐伤品瓮饨Y(jié)核鑒別的輔助診斷工具,具有較高的靈敏度,但在不同感染部位的檢測(cè)效能不同。T細(xì)胞斑點(diǎn)試驗(yàn)檢測(cè)結(jié)果受到患者免疫功能狀態(tài)與年齡的影響,因此在進(jìn)行該項(xiàng)檢測(cè)之前有必要對(duì)患者免疫狀態(tài)等相關(guān)因素進(jìn)行評(píng)估。
[Abstract]:Objective to investigate the efficacy of interferon gamma release test (T cell dot test) in the diagnosis of extrapulmonary tuberculosis. Methods the diagnostic efficacy of this technique in extrapulmonary tuberculosis and the risk factors affecting the results were analyzed by T cell dot test in 265 suspected patients with extrapulmonary tuberculosis. Results among 265 patients, 147 cases were diagnosed as extrapulmonary tuberculosis, 32 cases as suspected extrapulmonary tuberculosis and 86 cases as excluding tuberculosis infection. After removing suspicious samples, the sensitivity and specificity of T cell dot test were 81% and 53%, respectively. Among them, the sensitivity of T cell dot test was the highest in both lymphoid tuberculosis and tuberculosis peritonitis (88%), and the sensitivity of tuberculosis pleurisy was the lowest (75%). The specificity of T cell dot test for detection of lymphoid tuberculosis was the highest (67%), while that of intestinal tuberculosis was the lowest (44%). In the population with low immune function, the sensitivity was significantly lower than that in the population with normal immune function (P 0.05). In addition, age (鈮，
本文編號(hào)：2483636
[Abstract]:Objective to investigate the efficacy of interferon gamma release test (T cell dot test) in the diagnosis of extrapulmonary tuberculosis. Methods the diagnostic efficacy of this technique in extrapulmonary tuberculosis and the risk factors affecting the results were analyzed by T cell dot test in 265 suspected patients with extrapulmonary tuberculosis. Results among 265 patients, 147 cases were diagnosed as extrapulmonary tuberculosis, 32 cases as suspected extrapulmonary tuberculosis and 86 cases as excluding tuberculosis infection. After removing suspicious samples, the sensitivity and specificity of T cell dot test were 81% and 53%, respectively. Among them, the sensitivity of T cell dot test was the highest in both lymphoid tuberculosis and tuberculosis peritonitis (88%), and the sensitivity of tuberculosis pleurisy was the lowest (75%). The specificity of T cell dot test for detection of lymphoid tuberculosis was the highest (67%), while that of intestinal tuberculosis was the lowest (44%). In the population with low immune function, the sensitivity was significantly lower than that in the population with normal immune function (P 0.05). In addition, age (鈮，
本文編號(hào)：2483636
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