【摘要】：目的:探討不同劑量國產(chǎn)普瑞巴林用于帶狀皰疹后神經(jīng)痛(post-herpetic neuralgia,PHN)治療的療效與安全性。方法:45例診斷為PHN且符合納入標準的患者經(jīng)知情同意,采用隨機數(shù)字表法分為小劑量組(n=15)、中劑量組(n=15)、大劑量組(n=15),分別給予225、300、450 mg/d國產(chǎn)普瑞巴林治療4周。于治療前,治療1、2、3、4周觀察患者療效及不良反應(yīng)。采用視覺模擬量表(visual analogue scale,VAS)、醫(yī)院焦慮抑郁量表(hospital anxiety and depression,HAD)、醫(yī)學結(jié)局研究(medical outcomes study,MOS)睡眠量表分別評估患者疼痛、焦慮與抑郁及睡眠狀況。結(jié)果:3個劑量組患者治療1、2、3、4周時VAS評分、MOS睡眠量表評分均較治療前下降,差異有統(tǒng)計學意義(P0.05);治療4周時3組患者HAD評分較治療前也有降低,差異有統(tǒng)計學意義(P0.05);但3個劑量組間VAS評分、疼痛緩解療效、MOS睡眠量表評分、HAD評分比較差異并無統(tǒng)計學意義(P0.05)。不良反應(yīng)以頭暈、口干、嗜睡為主,多為一過性。3組間比較,頭暈、口干、嗜睡各不良反應(yīng)間差異有統(tǒng)計學意義(P0.05),余不良反應(yīng)間差異無統(tǒng)計學意義(P0.05)。結(jié)論:不同劑量國產(chǎn)普瑞巴林均可減輕PHN患者疼痛,改善焦慮、抑郁、睡眠,其療效不一定為劑量依賴性,而其不良反應(yīng)為輕中度且能自行緩解。
[Abstract]:Objective: to evaluate the efficacy and safety of different doses of domestic prednisone in the treatment of post-herpetic neuralgia (post-herpetic neuralgia,PHN). Methods: with informed consent, 45 patients diagnosed as PHN were randomly divided into three groups: low dose group (n = 15), middle dose group (n = 15) and high dose group (n = 15). The patients were treated with 225300450 mg/d domestic Prubalin for 4 weeks. Before treatment, 1, 2, 3, 4 weeks after treatment, the curative effect and adverse reaction were observed. Visual analogue scale (visual analogue scale,VAS), Hospital anxiety and Depression scale (hospital anxiety and depression,HAD) and Medical outcome study (medical outcomes study,MOS) were used to evaluate the pain, anxiety, depression and sleep status of the patients. Results: after 1, 2, 3, 4 weeks of treatment, the scores of VAS and MOS sleep scale were significantly lower in the three dose groups than those before treatment (P0.05). 4 weeks after treatment, the HAD scores of the three groups were also lower than those before treatment, the difference was statistically significant (P0.05). However, there was no significant difference in VAS score, pain relief effect, MOS sleep scale score and HAD score among the three dose groups (P0.05). The adverse reactions were dizziness, dry mouth, lethargy, mostly transient. There were significant differences in dizziness, dry mouth and somnolence among the three groups (P0.05), but there was no significant difference among the other adverse reactions (P0.05). Conclusion: different doses of domestic prednisolone can relieve pain, improve anxiety, depression and sleep in patients with PHN. The curative effect is not necessarily dose-dependent, but its adverse reactions are mild to moderate and can be alleviated by itself.
【作者單位】： 重慶醫(yī)科大學附屬第一醫(yī)院疼痛科;
【分類號】：R752.12

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