【摘要】：[目的]探討乙型肝炎后肝硬化患者的小腸細(xì)菌過(guò)度生長(zhǎng)(SIBO)情況,以及SIBO與其肝功能狀況、HBV-DNA之間的關(guān)系。[方法]將42例乙型肝炎后肝硬化患者按肝功能Child-Pugh分級(jí)分為A級(jí)、B級(jí)、C級(jí)三組,并入選同期門(mén)診體檢的健康者20例作為健康對(duì)照組。通過(guò)葡萄糖氫呼氣試驗(yàn)(GHBT)檢測(cè)并比較分析各組SIBO情況,同時(shí)檢測(cè)并比較分析肝硬化患者各組的HBV-DNA水平及其SIBO陽(yáng)性率。[結(jié)果]肝硬化各組患者與健康對(duì)照組的SIBO陽(yáng)性率及試餐后呼氣氫濃度比較均差異有統(tǒng)計(jì)學(xué)意義(P0.05)。肝硬化患者的SIBO陽(yáng)性率及試餐后呼氣氫濃度均隨著Child-Pugh分級(jí)低下而呈漸進(jìn)性增高,各組間差異有統(tǒng)計(jì)學(xué)意義(P0.05)。肝硬化患者各組間的SIBO陽(yáng)性率及試餐后呼氣氫濃度比較,HBV-DNA10~3時(shí)均明顯高于HBV-DNA≤10~3時(shí),且差異有統(tǒng)計(jì)學(xué)意義(P0.05)。[結(jié)論]乙型肝炎后肝硬化患者常存在SIBO,且隨著肝功能惡化、HBV-DNA拷貝數(shù)增加,其SIBO加重,由此推測(cè)防治SIBO,可能對(duì)乙型肝炎后肝硬化患者的肝功能改善、乙肝病毒清除有益。
[Abstract]:[Objective] To study the intestinal bacterial overgrowth (SIBO) in patients with liver cirrhosis after hepatitis B and the relationship between SIBO and its liver function and HBV-DNA. [Methods] 42 patients with liver cirrhosis were divided into three groups: A, B and C according to Child-Pugh of liver function. The serum levels of HBV-DNA and the positive rate of SIBO in each group of patients with liver cirrhosis were detected and compared by a glucose-hydrogen-exhale test (GHBT). [Results] The positive rate of SIBO in the patients with liver cirrhosis and the healthy control group were significantly different from those in the healthy control group (P <0.05). The positive rate of SIBO in patients with liver cirrhosis and the concentration of expiratory hydrogen in the post-meal were increased with the low grade of Child-Pugh, and there was a significant difference among the groups (P <0.05). The positive rate of SIBO in patients with liver cirrhosis was significantly higher than that of HBV-DNA (10-3), and the difference was statistically significant (P0.05). [Conclusion] SIBO is often present in the patients with liver cirrhosis after hepatitis B, and with the deterioration of the liver function, the number of HBV-DNA copies is increased, and the SIBO of the patients with liver cirrhosis is increased, so it is presumed that the prevention and control of SIBO may be beneficial to the improvement of liver function and the elimination of hepatitis B virus in the patients with liver cirrhosis after hepatitis B.
【作者單位】： 解放軍第169醫(yī)院湖南師范大學(xué)附屬湘南醫(yī)院消化內(nèi)科;
【分類號(hào)】：R512.62;R575.2
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本文編號(hào)：2448369