【摘要】：目的了解血液病合并侵襲性真菌感染(IFI)的現(xiàn)狀,分析真菌耐藥情況及感染的危險(xiǎn)因素。方法回顧性分析2006—2010年某院血液病科合并感染的患者1 246例次,對(duì)IFI患者病原學(xué)特點(diǎn)及危險(xiǎn)因素進(jìn)行分析。結(jié)果真菌感染281例次,分離真菌162株,感染部位以呼吸道(134株,占82.72%)為主。4種主要酵母菌為白假絲酵母菌、熱帶假絲酵母菌、光滑假絲酵母菌和克柔假絲酵母菌;2006—2009年均以白假絲酵母菌為主,2010年非白假絲酵母菌超過白假絲酵母菌。4種主要酵母菌對(duì)氟康唑和伊曲康唑的總耐藥率分別為5.15%和4.41%,6株克柔假絲酵母對(duì)氟康唑和伊曲康唑全部耐藥,未發(fā)現(xiàn)對(duì)伏立康唑耐藥的菌株。真菌感染的獨(dú)立危險(xiǎn)因素為合并糖尿病、粒缺時(shí)間14 d。結(jié)論血液病患者非白假絲酵母菌感染比例增加,出現(xiàn)了耐氟康唑和伊曲康唑的非白假絲酵母菌,需采取綜合措施積極預(yù)防及早期治療IFI患者。
[Abstract]:Objective to investigate the status of (IFI) in hematologic diseases complicated with invasive fungal infection, and to analyze the drug resistance of fungi and the risk factors of infection. Methods A retrospective analysis was made on 1 246 cases of hematological diseases complicated with infection in a hospital from 2006 to 2010. The etiological characteristics and risk factors of patients with IFI were analyzed. Results 162 strains of fungi were isolated from 281 cases of fungal infection. The main infection sites were respiratory tract (134 strains, 82.72%). The four main yeast species were Candida albicans, Candida tropicalis, Candida smooth Candida and Candida krostri. In 2006-2009, the main yeasts were Candida albicans. In 2010, non-Candida cerevisiae exceeded Candida albicans. The total drug resistance rates of four major yeasts to fluconazole and itraconazole were 5.15% and 4.41%, respectively. All 6 strains of Candida krolimus were resistant to fluconazole and itraconazole. The independent risk factor for fungal infection was diabetes mellitus, with a duration of 14 days. Conclusion the infection rate of non-white Candida cerevisiae in patients with hematologic diseases was increased, and fluconazole-resistant and itraconazole-resistant non-white Candida cerevisiae were found. It is necessary to take comprehensive measures to prevent and treat the patients with IFI at an early stage.
【作者單位】： 海軍總醫(yī)院;青島大學(xué)附屬醫(yī)院;
【分類號(hào)】：R519

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 王毅;江田;郭鳳麗;朱嬌陽;;腫瘤醫(yī)院醫(yī)院深部真菌感染分析[J];中國(guó)感染控制雜志;2010年04期

2 封蔚瑩;高建紅;鐘永根;傅佳萍;羅洪強(qiáng);劉忠民;;血液病房醫(yī)院真菌感染的特征與危險(xiǎn)因素分析[J];中華醫(yī)院感染學(xué)雜志;2012年11期

3 李鵬;陳立兵;杜明梅;邢玉斌;索繼江;曹圣山;劉伯偉;劉運(yùn)喜;;成年血液病患者醫(yī)院感染危險(xiǎn)因素分析[J];中華醫(yī)院感染學(xué)雜志;2013年12期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王文;趙自云;;呼吸道標(biāo)本分離的假絲酵母菌分布及耐藥性[J];中國(guó)感染控制雜志;2013年02期

2 程磊;王芳;;3190份呼吸道標(biāo)本真菌感染狀況及藥敏結(jié)果分析[J];包頭醫(yī)學(xué)院學(xué)報(bào);2015年03期

3 Daniele Bianchi;Giuseppe Vespasiani;Pierluigi Bove;;Acute kidney injury due to bilateral ureteral obstruction in children[J];World Journal of Nephrology;2014年04期

4 劉榮華;關(guān)麗;張亞慶;江水明;;惡性腫瘤患者侵襲性真菌感染危險(xiǎn)因素分析[J];現(xiàn)代腫瘤醫(yī)學(xué);2015年22期

5 田國(guó)燕;章亮;封愛英;;血液科醫(yī)院感染特點(diǎn)及影響因素[J];中華醫(yī)院感染學(xué)雜志;2014年08期

6 花京剩;;血液疾病患者并發(fā)侵襲性真菌感染的臨床分析[J];中國(guó)高等醫(yī)學(xué)教育;2014年03期

7 楊柳;舒航;吳冠宇;谷和先;張波;洪有軍;鄧娜;;139例惡性血液病患者院內(nèi)感染的回顧性分析[J];皖南醫(yī)學(xué)院學(xué)報(bào);2014年04期

8 施鵬飛;錢申賢;黃細(xì)蓮;劉利蓉;;血液腫瘤并發(fā)念珠菌血癥12例臨床分析[J];中國(guó)鄉(xiāng)村醫(yī)藥;2014年20期

9 張明;周華;楊青;沈毅弘;周建英;;念珠菌血癥的危險(xiǎn)因素和預(yù)后分析[J];中國(guó)微生態(tài)學(xué)雜志;2014年11期

10 封蔚瑩;洪攀;傅佳萍;羅洪強(qiáng);鐘永根;;血液病患者合并帶狀皰疹的臨床特征與危險(xiǎn)因素分析[J];中華醫(yī)院感染學(xué)雜志;2015年08期

相關(guān)博士學(xué)位論文 前1條

1 賈宇;RTA2基因降低白念珠菌對(duì)氟康唑敏感性的機(jī)制研究[D];第二軍醫(yī)大學(xué);2013年

相關(guān)碩士學(xué)位論文 前6條

1 梁s，

本文編號(hào)：2362083