【摘要】：目的探討HIV感染者和AIDS患者外周血T淋巴細胞活化亞群與病毒載量相關性。方法 2012年6-8月選擇河南省某AIDS高發(fā)地區(qū)HIV感染者322例和AIDS患者87例為研究對象,分別采用流式細胞儀和全自動病毒載量儀檢測HIV感染者和AIDS患者外周血T淋巴細胞及其活化亞群和血漿病毒載量,根據(jù)病毒載量水平將研究對象分為Ⅰ-Ⅳ組。結果HIV感染者與AIDS患者CD_3~+T細胞相對值、CD_(28)~+/CD_4~+比較,差異無統(tǒng)計學意義(P0.05)。HIV感染者淋巴細胞絕對值和相對值、CD_3~+T細胞絕對值、CD_3~+CD_8~+T細胞絕對值、CD_3~+CD_4~+T細胞絕對值和相對值、CD_3~+CD_4~+CD_8~+T細胞絕對值均高于AIDS患者,CD_3~+CD_8~+T細胞相對值低于AIDS患者,輔助性T細胞與抑制性T細胞比值(H/S)、CD_(28)~+/CD_8~+高于AIDS患者,CD_(38)~+/CD_8~+低于AIDS患者,差異均有統(tǒng)計學意義(P0.05)。各組淋巴細胞絕對值和相對值、CD_3~+T細胞相對值、CD_3~+CD_8~+T細胞相對值、CD_3~+CD_4~+T細胞絕對值和相對值及H/S、CD_(28)~+/CD_4~+、CD_(28)~+/CD_8~+、CD_(38)~+/CD_8~+比較,差異均有統(tǒng)計學意義(P0.05)。CD_3~+T細胞相對值、CD_3~+CD_8~+T細胞相對值及CD_(38)~+/CD_8~+與病毒載量水平呈正相關(r_s=0.128、0.291、0.409,P0.05);CD_3~+CD_4~+T細胞絕對值和相對值、H/S、CD_(28)~+/CD_4~+、CD_(28)~+/CD_8~+與病毒載量水平呈負相關(r_s=-0.246、-0.318、-0.297、-0.184、-0.204,P0.05)。結論 HIV感染者和AIDS患者T淋巴細胞活化過程發(fā)生變化;隨著病毒載量水平變化,HIV感染者和AIDS患者的T淋巴細胞活化亞群水平也不同。
[Abstract]:Objective to investigate the correlation between T lymphocyte activation subsets and viral load in HIV infected patients and AIDS patients. Methods 322 cases of HIV infection and 87 cases of AIDS in a high incidence area of AIDS in Henan Province were selected from June to August 2012. The peripheral blood T lymphocytes and their activated subsets and plasma viral load of HIV infected patients and AIDS patients were detected by flow cytometry and automatic virus loading instrument, respectively. According to the viral load level, the subjects were divided into group 鈪，

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