【摘要】：目的:了解患者行異基因造血干細(xì)胞移植術(shù)(HSCT)后發(fā)生侵襲性真菌感染(IFI)的發(fā)病率、危險因素及轉(zhuǎn)歸情況。方法:選擇我院2005年1月至2014年9月進(jìn)行HSCT的79例資料較完整的血液病患者的臨床資料進(jìn)行回顧性分析,分析HSCT患者發(fā)生IFI的臨床特征、危險因素和轉(zhuǎn)歸。結(jié)果:診斷IFI患者共計17例,其中臨床診斷者13例,擬診4例。感染發(fā)生的中位時間為移植后112 d(9-1931 d)。非感染組及感染組的非復(fù)發(fā)生存率分別為61.2%、35.2%。根據(jù)單因素分析:配型、Ⅱ-Ⅳ度a GVHD是發(fā)生IFI的危險因素,性別、原發(fā)病、感染前使用糖皮質(zhì)激素的量是患者發(fā)生死亡的危險因素。多因素分析顯示配型、Ⅱ-Ⅳ度a GVHD是發(fā)生IFI的危險因素,感染前使用糖皮質(zhì)激素量是患者發(fā)生死亡的危險因素。結(jié)論:具有多種危險因素的患者更易發(fā)生IFI,感染前使用較大劑量的免疫抑制劑者更易發(fā)生死亡。避免危險因素及回顧患IFI前30 d內(nèi)使用免疫抑制劑情況可使患者有較好的預(yù)后。
[Abstract]:Objective: to investigate the incidence, risk factors and outcome of invasive fungal infection (IFI) after allogeneic hematopoietic stem cell transplantation (HSCT). Methods: the clinical data of 79 patients with HSCT from January 2005 to September 2014 were retrospectively analyzed, and the clinical characteristics, risk factors and outcome of IFI in HSCT patients were analyzed. Results: a total of 17 patients with IFI were diagnosed, of whom 13 were clinically diagnosed and 4 were expected to be diagnosed. The median time of infection was 112d after transplantation (9-1931 d). The non-recurrence survival rate in non-infection group and infection group was 61. 2% and 35. 2%, respectively. According to univariate analysis, type 鈪，

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