【摘要】：目的掌握四川口岸入境外籍人群HCV感染情況及流行病學特征。探討廣東、深圳、云南、四川、遼寧口岸2010-2012年入境外籍人員抗-HCV陽性人員的抗-HCV、HCV-RNA載量及ALT三者的相關性,對口岸入境外籍人員更科學合理有效地開展丙肝傳染病監(jiān)測起好指導作用。方法對2010-2012年監(jiān)測的四川口岸入境外籍人群HCV陽性檢出者流行病學資料進行統(tǒng)計學分析。收集五大國境口岸保健中心篩查的235例抗-HCV陽性的入境外籍人員血清樣本,用酶聯(lián)免疫吸附測定(ELISA)法進行抗-HCV復檢,用實時熒光定量PCR法檢測HCV-RNA,同時收集其丙氨酸氨基轉(zhuǎn)移酶(ALT)檢測數(shù)據(jù)。數(shù)據(jù)采用SAS 9.13處理。結(jié)果 2010-2012年監(jiān)測的四川口岸入境外籍人群HCV感染率是2.8‰,51~60歲年齡組,來華留學人員感染率最高。收集的235例抗-HCV陽性入境外籍人員血清標本復檢后231例陽性,4例陰性。檢出HCV-RNA陽性131例(占56.7%),其中ALT異常89例(占67.9%)。100例HCV-RNA陰性中ALT異常25例(占25.0%)。隨著HCV-RNA載量的升高,ALT異常率有增高趨勢(χ2=44.75,P0.01)。同時,ALT的均值隨HCV-RNA載量的增加而升高(r=0.973,P0.01)。結(jié)論 HCV-RNA檢出率與方法學敏感性、HCV感染所處的臨床階段、抗病毒藥物的應用密切相關。HCV-RNA載量與ALT水平呈明顯相關性。入境外籍人群中51~60歲年齡組,來華留學人員陽性檢出率最高,提示在今后口岸HCV防控與分子流行病學分析工作中,可考慮將其作為重點監(jiān)測對象。
[Abstract]:Objective to understand the prevalence and epidemiological characteristics of HCV infection in foreign population at Sichuan Port. To explore the correlation among anti HCV load and ALT of foreign nationals in Guangdong, Shenzhen, Yunnan, Sichuan and Liaoning ports from 2010 to 2012. It plays a guiding role in developing surveillance of hepatitis C infectious disease more scientifically, reasonably and effectively for foreigners entering the port. Methods Epidemiological data of HCV positive people in Sichuan port from 2010 to 2012 were analyzed statistically. The serum samples of 235 foreign immigrants who were positive for anti-HCV were collected from five national border port health care centers. The serum samples of anti-HCV were re-examined by (ELISA) assay by enzyme-linked immunosorbent assay (Elisa). Real-time fluorescence quantitative PCR method was used to detect HCV-RNA, and (ALT) data of alanine aminotransferase were collected at the same time. The data were processed by SAS 9.13. Results the HCV infection rate of the foreign population in Sichuan port was 2.8 鈥，

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