【摘要】：目的了解蓬萊市健康人群發(fā)熱伴血小板減少綜合征布尼亞病毒(SFTSV)感染情況,并分析其分布規(guī)律及流行因素,為控制疫情提供理論依據(jù)。方法采用多階段整群隨機(jī)抽樣方法抽取健康人群1 525人,采集其血液標(biāo)本并分離血清,采用間接酶聯(lián)免疫吸附實(shí)驗(yàn)(ELISA)檢測(cè)人群中新布尼亞病毒特異性Ig G抗體,并采用統(tǒng)計(jì)學(xué)方法對(duì)不同年齡組人群、不同時(shí)間采集人群血清抗體陽(yáng)性率進(jìn)行比較。結(jié)果 1 525人份血清中,新布尼亞病毒特異性Ig G抗體陽(yáng)性138份,陽(yáng)性率為9.05%,男性人群抗體陽(yáng)性率為9.28%(61/657),女性抗體陽(yáng)性率為8.87%(77/868),兩者差異無(wú)統(tǒng)計(jì)學(xué)意義(χ2=0.078,P0.05)。各年齡組人群均有感染,以61~70歲年齡組人群新布尼亞病毒抗體陽(yáng)性率最高,各年齡組人群抗體陽(yáng)性率組間的差異具有統(tǒng)計(jì)學(xué)意義(χ2=46.86,P0.05),農(nóng)民抗體陽(yáng)性率明顯高于學(xué)生(χ2=6.45,P0.05),流行后期人群抗體陽(yáng)性率高于流行期人群抗體水平(χ2=9.36,P0.01)。結(jié)論蓬萊市健康人群中發(fā)熱伴血小板減少綜合征布尼亞病毒抗體陽(yáng)性率較高,提示大多數(shù)SFTSV病毒感染后宿主體內(nèi)產(chǎn)生的抗體可能會(huì)持續(xù)較長(zhǎng)時(shí)間,為我們了解疾病的發(fā)生、發(fā)展規(guī)律提供了基礎(chǔ)的理論數(shù)據(jù)。該病毒在蓬萊市流行強(qiáng)度較強(qiáng),應(yīng)引起高度重視。
[Abstract]:Objective to investigate the prevalence of (SFTSV) infection of fever associated with thrombocytopenia syndrome (SFTSV) in a healthy population of Penglai City, and to analyze its distribution and epidemic factors so as to provide a theoretical basis for the control of the epidemic situation. Methods Serum samples were collected from 1 525 healthy people by multistage cluster random sampling. The specific Ig G antibody of Neobania virus was detected by indirect enzyme-linked immunosorbent assay (ELISA). The positive rates of serum antibodies in different age groups and different time groups were compared by statistical method. Results among 1 525 serum samples, 138 samples were positive for Ig G antibody, the positive rate was 9.05. The positive rate of antibody was 9.28% (61 / 657) in male and 8.87% (77 / 868) in female. There was no significant difference between the two groups (蠂 2 / 0.078 P 0.05). The positive rate of new Bunia virus antibody was the highest in the 61- 70 age group. The positive rate of antibody in farmers was significantly higher than that in students (蠂 2 + 6.45%, P < 0.05), and the positive rate of antibody in the later period of epidemic was higher than that in the epidemic period (蠂 2 9. 36% P 0.01). The positive rate of antibody in different age groups was statistically significant (蠂 2 + 46.86% P < 0.05), and the positive rate of peasant antibody was significantly higher than that of students (蠂 2 + 6.45% P 0.05). Conclusion the positive rate of antibodies against Bunia virus in patients with fever and thrombocytopenia syndrome is higher in the healthy population of Penglai, suggesting that the antibodies produced in the host may last for a long time after the infection of SFTSV virus, which is helpful for us to understand the occurrence of the disease. The law of development provides basic theoretical data. The epidemic intensity of the virus in Penglai City is relatively strong, which should be attached great importance to.
【作者單位】： 蓬萊市疾病預(yù)防控制中心;山東省疾病預(yù)防控制中心;
【基金】：國(guó)家自然科學(xué)青年基金項(xiàng)目(81102171) 山東省醫(yī)藥衛(wèi)生科技發(fā)展計(jì)劃(2011HZ055) 山東省科學(xué)技術(shù)發(fā)展計(jì)劃(2012GHZ30031)
【分類號(hào)】：R510

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本文編號(hào)：2277672