【摘要】：目的:觀察胸腺五肽輔助治療痰涂片鏡檢抗酸桿菌陽(yáng)性(簡(jiǎn)稱菌陽(yáng))肺結(jié)核的臨床療效及對(duì)機(jī)體免疫功能的影響。方法:選擇160例菌陽(yáng)肺結(jié)核患者,隨機(jī)分為觀察組和對(duì)照組各80例,對(duì)照組采用單純化療方案治療,觀察組在對(duì)照組的基礎(chǔ)上聯(lián)合胸腺五肽治療,觀察兩組患者臨床療效及免疫功能改善情況。結(jié)果:治療后觀察組臨床癥狀消失情況明顯好于對(duì)照組(P0.05),不良反應(yīng)發(fā)生率明顯低于對(duì)照組(P=0.036 4),痰菌轉(zhuǎn)陰率在治療后隨訪的各個(gè)時(shí)間段均明顯高于對(duì)照組(P0.05),治療總有效率明顯高于對(duì)照組(P=0.000 0);治療后觀察組CD3~+、CD4~+和CD4~+/CD8~+水平均明顯高于治療前和治療后的對(duì)照組,而CD8~+水平均明顯低于治療前和治療后的對(duì)照組(P0.05);兩組患者均未發(fā)生明顯的不良反應(yīng)。結(jié)論:胸腺五肽輔助治療菌陽(yáng)肺結(jié)核可顯著增強(qiáng)患者免疫功能,改善患者臨床癥狀與體征,提高臨床治療效果,值得臨床推廣使用。
[Abstract]:Objective: to observe the clinical effect of thymus pentapeptide in the treatment of sputum smear positive acid-fast bacilli positive pulmonary tuberculosis and its effect on immune function. Methods: 160 patients with bacillus positive pulmonary tuberculosis were randomly divided into two groups: the observation group (n = 80) and the control group (n = 80). The control group was treated with chemotherapy alone, and the observation group was treated with thymus pentapeptide on the basis of the control group. The clinical effect and immune function of the two groups were observed. Results: after treatment, the clinical symptoms disappeared significantly better in the observation group than in the control group (P0.05), and the incidence of adverse reactions was significantly lower than that in the control group (P0.0364). The sputum negative rate was significantly higher in the observation group than in the control group during the follow-up period (P0.05). The effective rate was significantly higher than that of the control group (P0. 000 0), the levels of CD3~ CD4 ~ and CD4~ / CD8 ~ in the observation group were significantly higher than those in the control group before and after treatment. However, the level of CD8~ was significantly lower than that of the control group before and after treatment (P0.05), and no significant adverse reactions occurred in both groups. Conclusion: the adjuvant treatment of bacterium-positive pulmonary tuberculosis with thymic pentapeptide can significantly enhance the immune function, improve the clinical symptoms and signs, and improve the clinical therapeutic effect, which is worth popularizing in clinic.
【作者單位】： 石家莊市第五醫(yī)院結(jié)核科;
【基金】：石家莊市科學(xué)技術(shù)研究基金資助項(xiàng)目(131461123)
【分類號(hào)】：R521

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 林海;76例初治菌陽(yáng)肺結(jié)核綜合療效分析[J];中國(guó)熱帶醫(yī)學(xué);2005年02期

2 宋建國(guó);;312例菌陽(yáng)肺結(jié)核家庭督導(dǎo)的療效[J];臨床肺科雜志;2006年03期

3 吳俊杰;趙俊;陳宇;張克榮;;老年菌陽(yáng)肺結(jié)核并發(fā)肺癌34例臨床分析[J];基層醫(yī)學(xué)論壇;2006年20期

4 姜治先,高玉清,史同祿;R—77—3九個(gè)月方案治療初治菌陽(yáng)肺結(jié)核42例療效觀察[J];哈爾濱醫(yī)藥;1992年03期

5 范培,鐘樹標(biāo);初治菌陽(yáng)肺結(jié)核短化實(shí)施分析[J];中國(guó)防癆雜志;1994年03期

6 胡峻予，葉存珍，，朱運(yùn)元;利噴丁治療初治菌陽(yáng)肺結(jié)核療效分析[J];河南預(yù)防醫(yī)學(xué)雜志;1994年04期

7 鄒興梅,陳賀蘭,李婉君,黃啟青,何瑜,楊瑞鋒;全程監(jiān)化治療菌陽(yáng)肺結(jié)核9234例[J];中國(guó)防癆雜志;2001年05期

8 靳鴻建,靳曉偉,陳愛玲,劉巍,段海霞;實(shí)施衛(wèi)生部項(xiàng)目對(duì)菌陽(yáng)肺結(jié)核治療延遲的影響[J];中國(guó)防癆雜志;2002年04期

9 熊玉華;90例菌陽(yáng)肺結(jié)核發(fā)現(xiàn)延遲分析[J];湖北預(yù)防醫(yī)學(xué)雜志;2004年04期

10 吳俐健,賈本智,李春林,李學(xué)波;左氧氟沙星化療方案治療初治菌陽(yáng)肺結(jié)核療效[J];臨床肺科雜志;2004年05期

相關(guān)會(huì)議論文 前10條

1 王道國(guó);田楓;劉倩;;新型板式抗結(jié)核組合藥治療菌陽(yáng)肺結(jié)核417例[A];2011年全國(guó)醫(yī)藥學(xué)術(shù)論壇交流會(huì)暨臨床藥學(xué)與藥學(xué)服務(wù)研究進(jìn)展培訓(xùn)班論文集[C];2011年

2 于偉華;周克強(qiáng);;160例初治菌陽(yáng)肺結(jié)核藥敏結(jié)果與療效研究[A];中國(guó)防癆協(xié)會(huì)全國(guó)學(xué)術(shù)會(huì)議大會(huì)學(xué)術(shù)報(bào)告[C];2001年

3 宋建國(guó);;312例菌陽(yáng)肺結(jié)核家庭督導(dǎo)療效觀察[A];上海市預(yù)防醫(yī)學(xué)會(huì)第二屆學(xué)術(shù)年會(huì)論文匯編[C];2006年

4 錢虹;;母牛分枝桿菌菌苗輔助治療老年菌陽(yáng)肺結(jié)核療效觀察[A];科技創(chuàng)新與產(chǎn)業(yè)發(fā)展（A卷）——第七屆沈陽(yáng)科學(xué)學(xué)術(shù)年會(huì)暨渾南高新技術(shù)產(chǎn)業(yè)發(fā)展論壇文集[C];2010年

5 周寶格;張瑞娥;;經(jīng)纖支鏡給藥配合全身化療對(duì)菌陽(yáng)肺結(jié)核治療的體會(huì)[A];中國(guó)防癆協(xié)會(huì)全國(guó)學(xué)術(shù)會(huì)議大會(huì)學(xué)術(shù)報(bào)告[C];2001年

6 李昕潔;;菌陽(yáng)肺結(jié)核患者強(qiáng)化治療后療效分析(摘要)[A];中華醫(yī)學(xué)會(huì)第六屆全國(guó)結(jié)核病學(xué)術(shù)大會(huì)論文匯編[C];2000年

7 王X;瑪衣努爾;;初治菌陽(yáng)肺結(jié)核治療探討(摘要)[A];中華醫(yī)學(xué)會(huì)第六屆全國(guó)結(jié)核病學(xué)術(shù)大會(huì)論文匯編[C];2000年

8 李復(fù)方;米國(guó)強(qiáng);韓順利;王艷偉;高文英;;含左氧氟沙星治療方案治療初治菌陽(yáng)肺結(jié)核療效觀察[A];2007年中國(guó)防癆協(xié)會(huì)全國(guó)學(xué)術(shù)會(huì)議論文集[C];2007年

9 鐘達(dá);;經(jīng)纖支鏡肺內(nèi)局部給藥治療初治菌陽(yáng)肺結(jié)核52例療效觀察(摘要)[A];中華醫(yī)學(xué)會(huì)結(jié)核病學(xué)分會(huì)2002年學(xué)術(shù)會(huì)議論文匯編[C];2002年

10 趙一紅;張保敏;黃潤(rùn)堂;;結(jié)核清方案治療重癥菌陽(yáng)肺結(jié)核療效觀察[A];中華醫(yī)學(xué)會(huì)結(jié)核病學(xué)分會(huì)2004年學(xué)術(shù)會(huì)議論文匯編[C];2004年

本文編號(hào)：2246673