發(fā)布時間：2018-09-17 17:47

【摘要】：大量的遺傳學研究表明,結(jié)核病是多基因和環(huán)境因素共同作用的結(jié)果。近年來,結(jié)核病易感基因及其單核苷酸多態(tài)性(SNP)位點研究成為熱點,但與易感性有確切關(guān)聯(lián)的基因和SNP報道較少,并且某些易感基因有種族、人群、地域分布的差異,不同種群或地區(qū)的局部研究得到的研究結(jié)論常不一致,甚至相反,因此,需要進一步尋找能廣泛適用的、有確切關(guān)聯(lián)的易感基因。鑒于此,需要在具備基因多樣性的實驗動物中進行初篩,然后在動物或人群中驗證。協(xié)同雜交(Collaborative Cross,CC)小鼠具有遺傳多樣性并且有清晰的背景基因數(shù)據(jù)庫,可為結(jié)核易感性研究提供新的工具。本綜述總結(jié)已報道的結(jié)核易感基因及其SNP的研究進展,展望CC小鼠在此研究的應(yīng)用和重要意義。
[Abstract]:A large number of genetic studies have shown that tuberculosis is the result of a combination of multiple genes and environmental factors. In recent years, the study of susceptibility genes and their single nucleotide polymorphisms (SNP) loci has become a hot spot. However, there are few reports of genes and SNPs that are closely related to susceptibility, and some susceptibility genes are different in race, population and geographical distribution. Local studies in different populations or regions often lead to inconsistent or even contradictory results, so further searches for susceptibility genes that can be widely applied and have a definite association are needed. CC) mice have genetic diversity and clear background gene database, which can provide a new tool for tuberculosis susceptibility research. This review summarizes the progress of reported tuberculosis susceptibility genes and their SNPs, and looks forward to the application and significance of CC mice in this study.
【作者單位】： 中國醫(yī)學科學院醫(yī)學實驗動物研究所國家中醫(yī)藥管理局人類疾病動物模型三級實驗室衛(wèi)計委人類疾病比較醫(yī)學重點實驗室新發(fā)再發(fā)傳染病動物模型研究北京市重點實驗室北京市人類重大疾病實驗動物模型工程技術(shù)研究中心中國醫(yī)學科學院結(jié)核病中心;
【基金】：中央級公益性事業(yè)單位院基本業(yè)務(wù)費(編號:2016ZX310183-2)
【分類號】：R52
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本文編號：2246662