【摘要】：目的探討利奈唑胺對耐甲氧西林葡萄球菌(methicillin resistant staphylococcus,MRS)感染患者降鈣素原(procalcitonin,PCT)水平影響。方法選擇在上海市第五人民醫(yī)院急診科入院治療的85例對MRS感染患者進(jìn)行分組作對照研究,對照組42例患者予萬古霉素進(jìn)行治療,研究組43例患者予利奈唑胺治療,2w為1個療程。對比分析2組患者的治療效果,探究利奈唑胺抗生素對MRS感染患者PCT水平影響。結(jié)果 2組退熱時間、細(xì)菌清除時間、細(xì)菌清除率及48h病死率比較差異無統(tǒng)計學(xué)意義。研究組ICU治療時間顯著短于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。2組總有效率比較差異無統(tǒng)計學(xué)意義。治療后,研究組PCT及C-反應(yīng)蛋白(C-reactive protein,CRP)水平顯著低于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論利奈唑胺對MRS感染患者血清降鈣素原水平有顯著降低的作用,具有較好的臨床治療效果。
[Abstract]:Objective to investigate the effect of linazolamide on the level of procalcitonin (procalcitonin,PCT) in patients with methicillin-resistant staphylococci (methicillin resistant staphylococcus,MRS) infection. Methods Eighty-five patients with MRS infection who were admitted to the emergency department of Shanghai Fifth people's Hospital were divided into two groups: control group (n = 42) and control group (n = 42) treated with vancomycin. In the study group, 43 patients were treated with linazolamide for 2 weeks as a course of treatment. To explore the effect of linazolamide antibiotics on PCT level in patients with MRS infection. Results there was no significant difference in antipyretic time, bacterial clearance rate and 48 h mortality between the two groups. The treatment time of ICU in the study group was significantly shorter than that in the control group, and the difference was statistically significant (P0.05). 2. There was no significant difference in the total effective rate between the two groups. After treatment, the levels of PCT and C-reactive protein (C-reactive protein,CRP) in the study group were significantly lower than those in the control group (P0.05). Conclusion the serum procalcitonin level in patients with MRS infection was significantly decreased by lenazolamide and had a good clinical effect.
【作者單位】： 上海市第五人民醫(yī)院急診科;
【分類號】：R515

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 張逸;陳景連;葉宇釗;;降鈣素原在感染性疾病中的臨床研究進(jìn)展[J];臨床和實驗醫(yī)學(xué)雜志;2012年08期

2 蔡偉娟;劉e，

本文編號：2227945