【摘要】：目的觀察自擬逐飲活血湯輔助治療結(jié)核性胸膜炎的臨床療效及對患者胸腔積液炎癥因子與肺功能的影響。方法將75例結(jié)核性胸膜炎患者隨機(jī)分為2組,對照組38例給予胸腔穿刺抽液術(shù)聯(lián)合抗結(jié)核藥物治療,觀察組37例在對照組治療基礎(chǔ)上加用逐飲活血湯治療,2組均以2周為1個療程,共治療3個療程。觀察2組治療前后中醫(yī)證候評分、用力肺活量(FVC)、第1秒用力呼氣容積(FEV1)、FEV1/FVC變化情況,檢測2組治療前后胸腔積液中腫瘤壞死因子-α(TNF-α)、C反應(yīng)蛋白(CRP)水平,統(tǒng)計2組治療后臨床療效及治療期間不良反應(yīng)發(fā)生情況。結(jié)果治療后2組中醫(yī)證候評分均顯著降低(P均0.05),FVC、FEV1及FEV1/FVC顯著提高(P均0.05),且觀察組改善情況均明顯優(yōu)于對照組(P均0.05);治療后2組TNF-α、CRP水平均顯著降低(P均0.05),且觀察組顯著低于對照組(P均0.05);觀察組治療總有效率顯著高于對照組(P0.05),不良反應(yīng)發(fā)生率顯著低于對照組(P0.05)。結(jié)論自擬逐飲活血湯可顯著改善結(jié)核性胸膜炎患者的中醫(yī)證候,提高肺功能,減輕炎癥反應(yīng),療效好,且不良反應(yīng)更少,值得臨床推廣應(yīng)用。
[Abstract]:Objective to observe the clinical effect of Zhuyin Huoxue decoction in treating tuberculous pleurisy and its influence on inflammatory factors and pulmonary function in pleural effusion. Methods Seventy-five patients with tuberculous pleurisy were randomly divided into two groups. 38 patients in the control group were treated with thoracic puncture and drainage combined with antituberculous drugs. In the observation group, 37 cases were treated with Zhuyin Huoxue decoction on the basis of the control group. All the 37 cases in the observation group were treated with 2 weeks as a course of treatment, with a total of 3 courses of treatment. The scores of TCM syndromes, forced vital capacity (FVC), forced expiratory volume (FEV1) and FEV1 / FVC were observed before and after treatment in both groups. The levels of tumor necrosis factor- 偽 (TNF- 偽) and C-reactive protein (CRP) in pleural effusion were measured before and after treatment. The clinical efficacy and adverse reactions during the treatment were analyzed in the two groups. Results after treatment, the scores of TCM syndromes in the two groups were significantly decreased (P 0.05), the FVCU FEV1 and FEV1 / FVC were significantly increased (P 0.05), and the improvement in the observation group was significantly better than that in the control group (P 0.05), and the level of TNF- 偽 -CRP in the two groups decreased significantly after treatment (all P 0.05), and the observation group showed significant improvement. The total effective rate of treatment in the observation group was significantly higher than that in the control group (P0.05), and the incidence of adverse reactions was significantly lower than that in the control group (P0.05). Conclusion Zhuyin Huoxue decoction can significantly improve the syndrome of tuberculous pleurisy, improve lung function, alleviate inflammatory reaction, have good curative effect, and have fewer adverse reactions, so it is worthy of clinical application.
【作者單位】： 陜西省結(jié)核病防治研究所;陜西省西安市胸科醫(yī)院;陜西省西安市中醫(yī)醫(yī)院;
【分類號】：R521.7

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