本文選題：抗艾滋病藥物 + 研發(fā)信息�。� 參考：《中國(guó)艾滋病性病》2015年12期

【摘要】：目的把握國(guó)際抗艾滋病藥物技術(shù)研發(fā)重點(diǎn)領(lǐng)域,為中國(guó)抗艾滋病藥物研發(fā)和發(fā)展提供信息依據(jù)。方法通過(guò)檢索Web of science數(shù)據(jù)庫(kù)、Innography數(shù)據(jù)庫(kù)和Thomson Reuters Cortellis數(shù)據(jù)庫(kù),利用Thomson data analysis對(duì)近5年抗艾滋病藥物的重點(diǎn)產(chǎn)品、研發(fā)綜合競(jìng)爭(zhēng)力等進(jìn)行分析。結(jié)果全球共有1846種抗艾滋病藥物,已上市78種,其中反轉(zhuǎn)錄酶抑制劑藥物最多,194種;其次是蛋白酶抑制劑,145種。適應(yīng)證除針對(duì)艾滋病病毒(HIV)感染外,還可針對(duì)乙型肝炎、丙型肝炎、腫瘤及免疫相關(guān)疾病。近5年共有21 378條抗艾滋病藥物專利,主要集中在藥物組分、HIV感染、可藥用鹽等方面。中國(guó)專利數(shù)量排名第二,中藥占比最大。企業(yè)在專利研發(fā)方面顯示出強(qiáng)勁的實(shí)力�？拱滩∷幬锏幕A(chǔ)研究有23 309篇文獻(xiàn),中國(guó)相關(guān)論文數(shù)量排名第三,法國(guó)、南非與加拿大的研究被關(guān)注度和影響力較高。結(jié)論老藥的更新?lián)Q代,復(fù)合制劑的研發(fā),以及安全、有效的免疫抑制劑篩選與研發(fā),是抗艾滋病藥物研發(fā)的主要趨勢(shì)。歐美發(fā)達(dá)國(guó)家在抗艾滋病藥物的基礎(chǔ)研究與產(chǎn)品研發(fā)上均處于絕對(duì)優(yōu)勢(shì)。中國(guó)在抗艾滋病藥物研發(fā)方面也取得了一定的成績(jī),與國(guó)家"十一五"以來(lái)對(duì)艾滋病研究部署不斷增強(qiáng)相吻合。
[Abstract]:Objective to grasp the international research and development field of anti-AIDS drugs and provide information basis for the development of anti-AIDS drugs in China. Methods by searching the web of science database and Thomson Reuters Cortellis database, Thomson data analysis was used to analyze the key products of anti-AIDS drugs in recent 5 years and the comprehensive competitiveness of R & D. Results there are 1846 kinds of anti-AIDS drugs in the world, 78 kinds of them have been listed, the most of them are reverse transcriptase inhibitors, and the next are proteinase inhibitors. The indications are not only for HIV infection, but also for hepatitis B, hepatitis C, tumor and immune-related diseases. In the last five years, there are 21,378 patents of anti-AIDS drugs, mainly concentrated in the components of HIV infection, medicinal salts and so on. The number of Chinese patents ranked second, Chinese medicine accounted for the largest proportion. Enterprises in patent research and development showed strong strength. There are 23,309 articles in basic research on anti-AIDS drugs, with China ranking third in the number of related papers, while France, South Africa and Canada have a high degree of attention and influence. Conclusion the main trend of anti-AIDS drug development is the renewal of old drugs, the research and development of complex preparations, and the screening and development of safe and effective immunosuppressants. Developed countries in Europe and the United States in the basic research and development of anti-AIDS drugs are in absolute advantage. China has also made some achievements in the research and development of anti-AIDS drugs, consistent with the increasing development of HIV / AIDS research and deployment since the 11th Five-Year Plan.
【作者單位】： 中國(guó)醫(yī)學(xué)科學(xué)院醫(yī)學(xué)信息研究所;
【基金】：科技部發(fā)展規(guī)劃司“科技計(jì)劃管理費(fèi)”項(xiàng)目~~
【分類(lèi)號(hào)】：R512.91

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本文編號(hào)：2097896