本文選題：獲得性免疫缺陷綜合征 + 生存現(xiàn)狀��； 參考：《中國(guó)全科醫(yī)學(xué)》2015年33期

【摘要】：目的探討南昌市抗病毒治療艾滋病患者的生存狀況及影響因素,為提高艾滋病抗病毒治療工作的效果提供參考依據(jù)。方法從中國(guó)疾病預(yù)防控制信息系統(tǒng)-艾滋病綜合防治信息系統(tǒng)中,選取2004年5月—2012年10月南昌市所有接受免費(fèi)抗病毒治療的符合納入與排除標(biāo)準(zhǔn)的艾滋病患者599例為研究對(duì)象。收集患者基本情況(如性別、年齡、婚姻狀況等)、患者臨床相關(guān)資料(如感染途徑、WHO臨床分期、抗病毒治療方案、機(jī)會(huì)性感染的種類、CD4+細(xì)胞計(jì)數(shù)等)、患者的生存結(jié)局(分為繼續(xù)治療、死亡、停藥、失訪)、生存時(shí)間。采用壽命表法計(jì)算患者的生存率,采用Cox比例風(fēng)險(xiǎn)回歸模型分析患者生存時(shí)間的影響因素。結(jié)果 599例患者感染途徑以性傳播〔473例(79.0%)〕為主;WHO臨床分期以Ⅲ期〔232例(38.7%)〕、Ⅳ期〔191例(31.9%)〕為主;抗病毒治療方案以3種抗病毒藥物聯(lián)用〔472例(78.8%)〕為主;機(jī)會(huì)性感染排在前3位的種類為持續(xù)或間斷發(fā)熱122例(20.4%)、結(jié)核病100例(16.7%)、持續(xù)腹瀉(1個(gè)月)41例(6.8%);CD4+細(xì)胞計(jì)數(shù)為(125.8±105.1)個(gè)/μl。隨訪截止時(shí),共有490例(81.8%)繼續(xù)治療,80例(13.4%)死亡,12例(2.0%)停藥,17例(2.8%)失訪;生存時(shí)間為(6.7±0.2)年,95%CI為(6.4,7.1)年。第1~5年累積生存率分別為90.24%、85.21%、82.80%、79.65%、76.92%。Cox比例風(fēng)險(xiǎn)回歸分析結(jié)果顯示,年齡、血源傳播(與其他傳播相比)、WHO臨床分期、持續(xù)腹瀉(1個(gè)月)、反復(fù)嚴(yán)重的細(xì)菌性肺炎、腦淋巴瘤或B細(xì)胞非霍奇金淋巴瘤是艾滋病患者生存時(shí)間的影響因素(P0.05)。結(jié)論南昌市抗病毒治療艾滋病患者5年后生存率較為穩(wěn)定。宜早發(fā)現(xiàn)、早診斷、早納入抗病毒治療;加強(qiáng)年齡較大者、血源傳播者、WHO臨床分期Ⅲ期及以上者、有機(jī)會(huì)性感染患者的治療和管理,確�？共《局委熜Ч�,有效提高艾滋病患者的生存率。
[Abstract]:Objective to explore the living conditions and influencing factors of anti-viral therapy for AIDS patients in Nanchang city, so as to provide reference for improving the effect of anti-viral therapy. Methods from the China Disease Prevention and Control Information system-AIDS Integrated Prevention and Control Information system, From May 2004 to October 2012, 599 AIDS patients who met the criteria of inclusion and exclusion of free antiviral therapy in Nanchang city were selected as the study objects. Collect the basic information of patients (such as sex, age, marital status, etc.), the clinical data of patients (such as the way of infection, WHO clinical stage, antiviral therapy, etc.), The type of opportunistic infection, such as CD4 cell count), survival outcome of the patient (divided into continued treatment, death, drug withdrawal, lost visit), survival time. Life table method was used to calculate the survival rate and Cox proportional risk regression model was used to analyze the influencing factors of survival time. Results in 599 patients, the main route of infection was sexually transmitted (473 cases (79.0%), and the clinical stage 鈪，

本文編號(hào)：2057162