本文選題：尖銳濕疣 + 人乳頭瘤病毒��； 參考：《寧夏醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的1.比較兩種治療方法對不同亞型的HPV病毒感染的尖銳濕疣的治療效果;2.明確低危型、高危型HPV感染及一重、多重HPV感染是否存在治療差異;3.統(tǒng)計兩種治療方法治療期間及治療結(jié)束后的病毒轉(zhuǎn)陰率;4.跟蹤隨訪統(tǒng)計患者半年內(nèi)的復(fù)發(fā)率,為臨床治療提供參考。對象與方法利用臨床病例對照的方法,將就診于寧夏醫(yī)科大學(xué)總醫(yī)院皮膚性病科門診的尖銳濕疣患者進行HPV分型檢測,并根據(jù)發(fā)病部位及分型結(jié)果篩選出符合入選標(biāo)準(zhǔn)的患者,按照就診順序隨機分成兩組,分別采用純中藥制劑派特靈及艾拉-光動力治療,并對兩組臨床療效進行觀察。一、對象本研究對象來自于2015年7月-2016年7月就診于寧夏醫(yī)科大學(xué)總醫(yī)院門診的尖銳濕疣患者,診斷標(biāo)準(zhǔn)參照《衛(wèi)生部尖銳濕疣診斷標(biāo)準(zhǔn)與處理原則(ws235-2003)》。二、方法根據(jù)HPV分型結(jié)果將符合以下條件的入選患者進行匹配:○1.感染HPV病毒亞型相同(包括低危型、高危型、單一型及混合型HPV感染);○2感染部位相同;○3性別相同。共選取50對匹配成功的患者,并將匹配患者按1:1隨機分入派特靈組和艾拉-光動力組。在治療滿一月后及治療滿四月后別再次采用流式熒光雜交法對100例尖銳濕疣患者疣體黏膜交界面脫落細胞或疣體組織進行HPV基因亞型的檢測,對比治療中期及治療后期病毒轉(zhuǎn)陰率及復(fù)發(fā)情況,進一步評價兩種治療方法的臨床療效。比較項目包括以下方面:1、一般資料的分析2、兩種治療方法臨床療效的比較3與其他人研究結(jié)果的比較統(tǒng)計學(xué)方法:所有數(shù)據(jù)的整理采用EXCEL表格,統(tǒng)計學(xué)計算應(yīng)用SPSS18.0軟件,對治療效果的比較采用卡方檢驗,以P0.05為差別有統(tǒng)計學(xué)意義。結(jié)果通過對兩組臨床療效比較,得出以下結(jié)果:1.50例派特靈組尖銳濕疣患者治療期間第一次復(fù)查HPV病毒陰性檢測率為48.0%(24/50,)第二次復(fù)查HPV陰性檢測率為94.00%(47/50),結(jié)合療效判斷標(biāo)準(zhǔn)總有效率為96.00%。50例艾拉-光動力組治療期間第一次復(fù)查HPV病毒陰性檢測率為32.0%(16/50,)第二次復(fù)查HPV陰性檢測率為78.00%(39/50),結(jié)合療效判斷標(biāo)準(zhǔn)總有效率為82.0%。比較兩組總體療效得出P0.05,派特靈組的總體治療效果優(yōu)于艾拉-光動力組。對艾拉-光動力組和派特靈組男性治療療效進行比較得出P0.05,派特靈在治療男性尖銳濕疣方面療效優(yōu)于艾拉-光動力組;對艾拉-光動力組和派特靈組對低危型別HPV感染的治療上進行比較,得出P0.05,派特靈組在低危型別HPV病毒感染的療效優(yōu)于艾拉-光動力組。對艾拉-光動力組和派特靈組對多重HPV感染的治療上進行比較,P0.05,派特靈組治療多重HPV感染的療效優(yōu)于艾拉-光動力組。2.分別對兩組治愈及顯效患者進行6個月的跟蹤隨訪,排除再次感染HPV病毒的可能性后,派特靈組復(fù)發(fā)2例,復(fù)發(fā)率為4.00%,艾拉-光動力組復(fù)發(fā)3例,復(fù)發(fā)率為6.00%。兩組患者復(fù)發(fā)率進行統(tǒng)計學(xué)比較,P0.05,兩組復(fù)發(fā)率無統(tǒng)計學(xué)差異。3.與他人研究情況比較,派特靈與艾拉-光動力治療均優(yōu)于傳統(tǒng)的液氮冷凍、激光、電灼等治療方法。結(jié)論1、兩種療法在治療尖銳濕疣方面都取得了很好的療效。2、兩種療法都對局部黏膜損害輕微,未破壞器官結(jié)構(gòu)、保持器官功能完整。3、兩組患者臨床療效上來看,派特靈組較艾拉-光動力組比具有病毒轉(zhuǎn)陰率高、有效率高的優(yōu)勢,對低危型別及混合型別感染的治療效果尤佳。4、派特靈治療時間短,易操作、病人自主性強、花費小等優(yōu)點,更容易被患者接受。
[Abstract]:Objective 1. to compare the therapeutic effects of two treatments on Condyloma Acuminata with different subtypes of HPV virus infection; 2. clear whether there is a difference in the treatment of low risk, high-risk HPV infection and one heavy, multiple HPV infection; 3. statistics of two treatments during and after the end of treatment; 4. follow up the follow-up statistics for half a year To provide reference for clinical treatment. Objects and methods using the method of clinical case control, the patients with condyloma acuminata in the dermatology department of Ningxia Medical University General Hospital were examined by HPV typing, and the patients were selected according to the location and classification results. The patients were randomly divided into two groups according to the order of medical treatment. Pdling and Ella photodynamic therapy were used to observe the clinical efficacy of two groups. First, the object of the study was from the patients of condyloma acuminata in the outpatient department of Ningxia Medical University General Hospital in July -2016 July 2015. The diagnostic criteria refer to the diagnostic criteria and treatment principles of condyloma acuminata in the Ministry of Health (ws235-2003) Two, the method was matched with the following conditions according to the HPV typing results: 0 1. infection of the HPV virus subtype (including low risk, high risk type, single type and mixed HPV infection); 0 2 infected sites identical; 0 3 sex identical. A total of 50 matched patients were selected and the matched patients were randomly divided into parling group according to 1:1 And Ella photodynamic group. After the treatment of 100 cases of condyloma acuminata patients with condyloma acuminatum after one month of treatment and after April, 100 cases of condyloma acuminata mucosa interface exfoliated cells or verrucous tissues were detected, and two kinds of treatment were compared in the middle and later period of treatment. The comparison project included the following aspects: 1, the analysis of the general data 2, the comparison of the clinical efficacy of the two kinds of treatment methods 3 and the comparison of other people's research results: all the data were collected by the EXCEL table, the statistical calculation was applied to the SPSS18.0 software, the comparison of the therapeutic effect was taken with the chi square test, and the P0.05 was poor. The results were compared with the two groups. The results were as follows: 1.50 cases of condyloma acuminata in putling group were first reexamined HPV virus negative detection rate was 48% (24/50), the second reexamination HPV negative detection rate was 94% (47/50). The total effective rate of the conclusion of the conclusion was 96.00%.50 Ella - photodynamic. The negative detection rate of HPV virus was 32% (16/50) for the first reexamination of the force group (16/50). The negative detection rate of HPV was 78% (39/50). The total effective rate of the therapeutic evaluation standard was 82.0%. compared with the total curative effect of two groups. The overall therapeutic effect of pate group was better than that of the Ella photodynamic group. The Ella photodynamic group and pdling group were better than the PDL group. The curative effect of the male group was compared with that of P0.05. Putling was better than the Ella photodynamic group in the treatment of male condyloma acuminatum. The treatment of the low risk HPV infection in the Ella photodynamic group and the putling group was compared, and the effect of P0.05 and putling group in the low risk type HPV virus infection was better than that of the Ella photodynamic group. The Ella - photodynamic group and pdling group were compared in the treatment of multiple HPV infection. P0.05 and pdling group were better than the Ella - photodynamic group.2. for two groups of cured and effectual patients, respectively. After eliminating the possibility of re infection of the HPV virus, 2 cases were recurred in the pdling group and the recurrence rate was 4 0%, the recurrence rate of the Ella - photodynamic group was 3 cases, the recurrence rate was 6.00%. two, the recurrence rate was statistically compared, P0.05, two groups had no statistical difference,.3. compared with others, pterin and Ella - photodynamic therapy were superior to traditional liquid nitrogen cryotherapy, laser, cauterization and other treatment methods. Conclusion 1, two treatments in the treatment of condyloma acuminata The two treatments were both mild to the local mucosa damage, without destroying the organ structure and maintaining the complete function of the organs.3. The clinical efficacy of the two groups of patients, compared with the Ella photodynamic group, was higher and the effective rate was higher than that of the two groups. In addition,.4 is more easily accepted by patients because of its advantages of short treatment time, easy operation, patient autonomy and low cost.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R752.53

【參考文獻】

相關(guān)期刊論文 前10條

1 許佳;;派特靈治療高危型HPV感染的臨床療效研究[J];中外醫(yī)療;2015年33期

2 陳思華;楊健;楊文林;;臨床尖銳濕疣流行病學(xué)與復(fù)發(fā)的相關(guān)危險因素的研究[J];中國性科學(xué);2015年07期

3 徐金華;;尖銳濕疣的復(fù)發(fā)與防治[J];中華皮膚科雜志;2015年05期

4 蔡為民;闞延靜;耿建祥;龍秀榮;梅靜;王宏景;夏林;王旭波;趙雪;;子宮頸尖銳濕疣組織中HPV感染基因型別分布[J];臨床與實驗病理學(xué)雜志;2015年04期

5 ;尖銳濕疣臨床診療與防治指南(一)[J];中國艾滋病性病;2015年02期

6 陳慧;陳靜;;派特靈與CO_2激光治療男性尖銳濕疣的臨床效果對比[J];中國性科學(xué);2014年06期

7 馬國安;王寶娟;丁紅煒;;光動力聯(lián)合療法在尖銳濕疣治療中的應(yīng)用[J];中國艾滋病性病;2014年02期

8 孟凡祥;;尖銳濕疣患者人乳頭瘤病毒的檢測與分型[J];蚌埠醫(yī)學(xué)院學(xué)報;2013年11期

9 畢曉東;陳日新;楊波濤;馬卉;劉成印;;派特靈聯(lián)合艾拉-光動力治療尖銳濕疣的臨床療效[J];中國艾滋病性病;2013年07期

10 徐楠;胡小利;覃兆偉;朱閩;;尖銳濕疣復(fù)發(fā)的防治進展[J];醫(yī)學(xué)綜述;2013年09期

，

本文編號：1979775