本文選題：結(jié)核 + 肺�。� 參考：《中國(guó)公共衛(wèi)生管理》2016年06期

【摘要】：目的了解長(zhǎng)春市住院肺結(jié)核患者結(jié)核分枝桿菌耐藥狀況,分析住院患者耐藥菌譜為進(jìn)一步指導(dǎo)臨床用藥方案提供依據(jù)。方法選擇2012年5月至2013年12月長(zhǎng)春市各縣區(qū)結(jié)防機(jī)構(gòu)推送及長(zhǎng)春市結(jié)核病定點(diǎn)醫(yī)院確診的長(zhǎng)春地區(qū)痰涂片陽(yáng)性肺結(jié)核患者801例,復(fù)治487例,初治314例,采用傳統(tǒng)羅氏國(guó)體培養(yǎng)法和比例法對(duì)痰標(biāo)本進(jìn)行結(jié)核分枝桿菌培養(yǎng)及藥物敏感試驗(yàn)。結(jié)果 801份痰標(biāo)本培養(yǎng)陽(yáng)性菌株747株,結(jié)核分枝桿菌中任意耐藥菌株426例(57.03%),其中初治患者和復(fù)治患者任意耐藥率分別為40.07%(115/287)、75.43%(347/460),復(fù)治患者任意耐藥率明顯高于初治患者(χ~2=93.67,P0.05)。初治患者與復(fù)治患者對(duì)異煙肼、利福平、氧氟沙星單耐藥率相近,差異無(wú)統(tǒng)計(jì)學(xué)意義。耐2種(χ~2=22.89)、耐3種(χ~2=75.98)及耐多藥(χ~2=88.37)、廣泛耐藥(χ~2=9.52)差異有統(tǒng)計(jì)學(xué)意義(P0.05),25~54歲耐多藥及廣泛耐藥率高于其他年齡段(P0.05)。結(jié)論涂陽(yáng)肺結(jié)核患者耐藥率嚴(yán)重,復(fù)治患者為主要耐藥人群,重癥初治涂陽(yáng)病人耐藥情況不容忽視。
[Abstract]:Objective to investigate the drug resistance of Mycobacterium tuberculosis in pulmonary tuberculosis patients in Changchun City, and to analyze the spectrum of drug resistance bacteria in patients with pulmonary tuberculosis. Methods from May 2012 to December 2013, 801 pulmonary tuberculosis patients with sputum smear positive in Changchun were selected, 487 cases were re-treated and 314 cases were initially treated. Mycobacterium tuberculosis culture and drug sensitivity test were carried out in sputum specimens by traditional Roche's body culture method and proportional method. Results among 801 sputum specimens, 747 strains were positive and 426 strains were arbitrarily resistant in Mycobacterium tuberculosis. Among them, the rate of arbitrary drug resistance was 40.07% in the first treatment group and 75.43% in the retard group (P 0.05). The rate of arbitrary drug resistance in the re-treated patients was significantly higher than that in the initial treatment patients (蠂 ~ 2P _ (93.67) P _ (0.05). The rates of isoniazid, rifampicin and ofloxacin resistance to isoniazid, rifampicin and ofloxacin were similar between primary and recurrent patients, but the difference was not statistically significant. The rates of multidrug resistance (MDR) and multidrug resistance (MDR) were significantly higher than those in other age groups (蠂 ~ (2 +) = 22.89, 蠂 ~ (2 +) = 75.98) and multidrug resistance (蠂 ~ (2 +) = 88. 37, 蠂 ~ (2 +) = 29. 52). The rates of multidrug resistance (MDR) and wide drug resistance (MDR) in 2554 years old were significantly higher than those in other age groups (P 0. 05). Conclusion the drug resistance rate of smear positive pulmonary tuberculosis patients is serious.
【作者單位】： 長(zhǎng)春市傳染病醫(yī)院;
【分類號(hào)】：R521
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本文編號(hào)：1881879