本文選題：艾滋病 + 艾滋病相關性腎病��； 參考：《山東醫(yī)藥》2017年09期

【摘要】：目的觀察HIVAN高效抗反轉錄病毒治療(HAART)前后人類免疫缺陷病毒相關性腎病(HIVAN)患者血清胱抑素C(Cystatin C)、糖類抗原-125(CA-125)水平變化并探討其意義。方法選取50例HIVAN患者(觀察組),應用羅氏全自動PPE生化儀,分別采用比濁法及電化學發(fā)光法檢測HAART治療前及治療后6個月血清Cystatin C、CA-125水平,并與同期健康體檢者50例(對照組)對比。采用COULTER EPICS XL型流式細胞儀測定CD4+T細胞數(shù)、CD4+T/CD8+T值。相關性分析采用Spearman相關分析法。結果觀察組治療前血清Cystatin C、CA-125水平明顯高于對照組(P均0.01);HAART治療6個月后,觀察組血清CA-125水平下降較明顯,與治療前比較(P0.05),而Cystatin C下降不明顯,與治療前比較差異無統(tǒng)計學意義(P0.05);CD4+T細胞數(shù)、CD4+T/CD8+T值升高明顯,與治療前比較差異有統(tǒng)計學意義(P均0.05)。相關分析結果提示,CD4+T細胞與hs-CRP、CA-125呈負相關(r分別為-3.326、-2.910,P均0.05);而CD4+T細胞與Cystatin C、Ccr、GFR無相關性(r分別為0.285、0.101、0.225,P均0.05)。GFR與Cystatin C、CA-125、hs-CRP呈負相關(r分別為-2.352、-4.022、-3.022,P均0.05)。結論 HAART治療前HIVAN患者血清Cystatin C、CA-125水平明顯升高,治療后血清CA-125水平下降明顯;監(jiān)測血清Cystatin C、CA-125水平,有助于觀察和評估HIVAN患者腎臟損害發(fā)生、進展和預后。
[Abstract]:Objective to observe the changes of serum levels of cystatin (C(Cystatin), carbohydrate antigen (-125) and carbohydrate antigen (CA-125) in patients with human immunodeficiency virus associated nephropathy (HIV HIVAN) before and after treatment of HAART with HIVAN and to explore its significance. Methods 50 patients with HIVAN were enrolled in the study group. The serum levels of Cystatin CA-125 were detected by turbidimetry and electrochemiluminescence before and 6 months after HAART treatment by using Roche automatic PPE biochemical instrument. The results were compared with 50 healthy persons (control group) in the same period. The number of CD4 T cells and CD4 T/CD8 T were measured by COULTER EPICS XL flow cytometry. Correlation analysis was performed by Spearman correlation analysis. Results the levels of serum Cystatin Con CA-125 in the observation group were significantly higher than those in the control group (P < 0.01). The serum CA-125 level in the observation group was significantly lower than that in the control group (P < 0.05), but Cystatin C was not significantly decreased in the observation group. There was no significant difference between before treatment and before treatment. The number of CD4 T/CD8 T cells and the number of CD4 T/CD8 T cells were significantly higher than those before treatment, and there was a significant difference between them before treatment and before treatment (P < 0.05). The results of correlation analysis showed that the negative correlation between CD4 T cells and hs-CRP CA-125 was -3.326- 2.910P, respectively, while there was no correlation between CD4 T cells and Cystatin Ccr-GFR (r = 0.2850.101 ~ 0.225P). The negative correlation between 0.05).GFR and Cystatin CCA-125hs-CRP was -2.352- 4.022- 3.022p, respectively. Conclusion before HAART treatment, the serum Cystatin Con CA-125 level in HIVAN patients was significantly increased, and the serum CA-125 level decreased significantly after treatment, and monitoring the serum Cystatin CnCA-125 level was helpful to observe and evaluate the occurrence, progression and prognosis of renal damage in HIVAN patients.
【作者單位】： 南寧市第四人民醫(yī)院·廣西艾滋病臨床治療中心;
【基金】：廣西壯族自治區(qū)衛(wèi)計委自籌經(jīng)費科研項目(Z2015168)
【分類號】：R512.91;R692

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