本文選題：棒狀光源 + 肛管��； 參考：《醫(yī)學(xué)研究生學(xué)報(bào)》2017年12期

【摘要】：目的肛管內(nèi)尖銳濕疣的治療難度大,復(fù)發(fā)率高,一直是臨床研究的重點(diǎn)。文中旨在觀察棒狀光源5-氨基酮戊酸光動(dòng)力療法(ALA-PDT)治療肛管內(nèi)尖銳濕疣的療效及安全性。方法收集2016年6月至2017年6月中國(guó)醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院皮膚病醫(yī)院理療科門診就診的肛管內(nèi)尖銳濕疣患者30例。每周一次棒狀光源ALA-PDT治療,每次治療前詳細(xì)記錄皮損情況,計(jì)算皮損清除率;同時(shí)記錄里急后重等相關(guān)不良反應(yīng)。平均隨訪時(shí)間(150±20)d,觀察復(fù)發(fā)情況。結(jié)果治療1次全部清除者6例(20.0%),部分清除者12例(40.0%),未清除者12例(40.0%);2次治療全部清除者11例(36.7%),部分清除者9例(30.0%),未清除者10例(33.3%);3次治療全部清除15例(50.0%),部分清除7例(23.3%),未清除8例(26.7%),3次治療總有效率為73.3%(22/30)。ALA-PDT治療期間27例均出現(xiàn)疼痛反應(yīng),治療后10 min達(dá)疼痛高峰,15 min后逐漸緩解,疼痛自覺模擬尺評(píng)分為(6.57±1.24)分,僅有1例患者疼痛難忍,疼痛評(píng)分10分。至隨訪結(jié)束時(shí)4例(18.2%)患者復(fù)發(fā),其中有2例僅在肛管復(fù)發(fā),2例肛周、肛管均有復(fù)發(fā)。結(jié)論棒狀光源ALA-PDT治療肛管內(nèi)尖銳濕疣療效好,安全性高,復(fù)發(fā)率低。
[Abstract]:Objective the treatment of condyloma acuminatum in anal canal is difficult and the recurrence rate is high. The purpose of this study was to observe the efficacy and safety of 5-aminolevulinic acid photodynamic therapy in the treatment of condyloma acuminatum in anal canal. Methods from June 2016 to June 2017, 30 patients with condyloma acuminatum in anal canal were collected from Department of Physiotherapy, Department of Physiotherapy, Peking Union Medical College, Chinese Academy of Medical Sciences. Once a week ALA-PDT was treated with rod light source. The lesions were recorded in detail before each treatment and the clearance rate was calculated. Meanwhile, the adverse reactions such as acute and severe injury were recorded at the same time. The mean follow-up time was 150 鹵20 days, and the recurrence was observed. Results six cases were completely cleared once, 12 cases were partially cleared, 12 cases were removed, 12 cases were not cleared, 11 cases were completely cleared, 9 cases were partially cleared, 15 cases were completely cleared, and 7 cases were partially cleared. The total effective rate was 23. 3% and 8 cases were not cleared. The total effective rate of 3 times treatment was that 27 cases had pain reaction during 73.3%(22/30).ALA-PDT treatment. After 10 min treatment, the pain peak reached 15 min and gradually relieved. The score of pain self-conscious simulation scale was 6.57 鹵1.24, and only one patient could not bear pain, and the pain score was 10 points. By the end of follow-up, 4 patients had recurred, 2 of them had recrudescence only in anal canal and 2 patients had recrudescence in anal canal. Conclusion ALA-PDT has good efficacy, high safety and low recurrence rate in the treatment of condyloma acuminatum in anal canal.
【作者單位】： 中國(guó)醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院皮膚病醫(yī)院理療科;
【基金】：江蘇省自然科學(xué)基金(BK20160152)
【分類號(hào)】：R752.53

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