本文選題：乙型肝炎表面抗原 + 乙型肝炎E抗原�。� 參考：《蘇州大學(xué)》2014年碩士論文

【摘要】：目的：探討HBsAg定量與HBeAg、HBVDNA、HBV基因型的相關(guān)性。 方法：收集2010年12月至2013年12月在泰興市人民醫(yī)院確診的154例乙肝病例,既往均未使用過(guò)抗乙肝病毒藥物。男113例,女41例,中位年齡38(17-70)歲。其中慢性乙型肝炎130例(輕度43例,中度47例,重度40例),肝硬化24例；HBeAg陽(yáng)性127例,HBeAg陰性27例；B基因型48例,C基因型104例,非B非C基因型2例。采用電化學(xué)發(fā)光法檢測(cè)HBsAg、 HBeAg定量,熒光定量PCR法測(cè)定HBVDNA定量、HBV基因型進(jìn)行統(tǒng)計(jì)學(xué)分析。 結(jié)果：1.HBsAg定量與HBeAg定量及HBVDNA定量均呈負(fù)相關(guān)關(guān)系(r=-0.42,P0.05:r=0.43,P0.05)。2.B基因型患者HBsAg定量與HBeAg定量呈負(fù)相關(guān)關(guān)系(r=-0.46,P0.05)、與HBVDNA定量無(wú)相關(guān)關(guān)系(r=-0.30,P0.05),C基因型患者HBsAg定量與HBeAg定量呈負(fù)相關(guān)關(guān)系(r=-0.39,P0.05)、與HBVDNA定量無(wú)相關(guān)關(guān)系(r=一0.24,P0.05)。3.在B、C基因型患者中,HBsAg定量分別為3767.4±2257.1COI,3548.2±2339.9COI,兩者相比差異無(wú)統(tǒng)計(jì)學(xué)意義(t=0.550, P=0.584)；HBeAg定量分別為437.6±452.5COI,521.4±438.6COI,兩者相比差異無(wú)統(tǒng)計(jì)學(xué)意義(t=1.072,P=0.287)；HBVDNA定量分別為6.7±1.410gIU/ml,6.7±1.2logIU/ml,兩者相比差異無(wú)統(tǒng)計(jì)學(xué)意義(t=-0.204,P=0.839)。4.與HBeAg陰性患者比較,HBeAg陽(yáng)性患者血清HBVDNA定量明顯增高(t=2.687,P0.05)。 結(jié)論：HBsAg定量與HBeAg定量、HBVDNA定量呈負(fù)相關(guān),與HBV基因型無(wú)相關(guān)。不同基因型之間HBsAg定量、HBeAg定量、HBVDNA定量無(wú)統(tǒng)計(jì)學(xué)差異。HBeAg陽(yáng)性患者血清HBVDNA定量顯著高于HBeAg陰性患者。
[Abstract]:Objective: to investigate the relationship between HBsAg quantification and HBV genotype in HBeAgN HBV DNA. Methods: 154 cases of hepatitis B diagnosed in Taixing people's Hospital from December 2010 to December 2013 were collected. There were 113 males and 41 females with a median age of 3817-70 years. There were 130 cases of chronic hepatitis B (mild 43 cases, moderate 47 cases, severe 40 cases), 24 cases of liver cirrhosis with HBeAg positive 127 cases with HBeAg negative 27 cases with HBeAg genotype 48 cases with C genotype and 104 cases with non-B non-C genotype (104 cases). HBsAg and HBeAg genotypes were detected by electrochemiluminescence assay and HBVDNA genotypes were detected by fluorescence quantitative PCR method. Results 1. There was a negative correlation between HBsAg quantification and HBeAg quantification and HBVDNA quantification. There was a negative correlation between HBsAg quantification and HBeAg quantification in patients with genotype HBeAg, but no correlation between HBsAg quantification and HBeAg quantification in HBVDNA genotype patients. There was a negative correlation between HBsAg quantification and HBeAg quantification in patients with genotype HBVDNA, and there was a negative correlation between HBsAg quantification and HBeAg quantification in patients with genotype B, and there was a negative correlation between HBsAg quantification and HBeAg quantification in patients with genotype HBeAg, and there was a negative correlation between HBsAg quantity and HBeAg quantification in patients with genotype HBeAg. There was no correlation between HBVDNA quantification and r = -0.24 (P0.05N. 3). The quantification of HBVDNA in the patients with genotype B was 3767.4 鹵2257.1COI 3548.2 鹵2339.9COI.There was no significant difference between the two groups. There was no significant difference between the two groups (437.6 鹵452.5COI, 521.4 鹵438.6COI, respectively). There was no significant difference in HBVDNA between the two groups (6.7 鹵1.410g / ml vs 6.7 鹵1.2logIUP / ml, respectively). There was no significant difference between the two groups. Compared with HBeAg negative patients, the serum HBVDNA of HBeAg positive patients was significantly higher than that of HBeAg negative patients. Conclusion there was a negative correlation between HBeAg DNA and HBeAg quantification, but no correlation with HBV genotypes. There was no statistical difference between different genotypes. The serum HBVDNA quantity of HBeAg positive patients was significantly higher than that of HBeAg negative patients.
【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R512.62

【共引文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前3條

1 俞立飛;替比夫定治療HBeAg陽(yáng)性慢性乙型肝炎患者e抗原血清學(xué)轉(zhuǎn)換的基線(xiàn)預(yù)測(cè)因素分析[D];浙江大學(xué);2014年

2 潘月;內(nèi)質(zhì)網(wǎng)分子伴侶PDIA3在非酒精性脂肪性肝病中的作用及機(jī)制研究[D];浙江大學(xué);2014年

3 曾林燕;浙江省慢性HBV感染者中乙型肝炎病毒表面抗原（HBsAg）水平的橫斷面研究[D];浙江大學(xué);2014年

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本文編號(hào)：1859036