本文選題：丙型肝炎病毒 + 包裝　； 參考：《武漢大學學報(理學版)》2015年03期

【摘要】：丙型肝炎病毒(HCV)是一種單股正鏈RNA病毒,是導致慢性肝炎的主要病原體之一.近年體外培養(yǎng)體系成功構(gòu)建后HCV分子生物學的研究獲得重要進展,HCV生活周期的各個步驟得到了深入研究.由于NS2蛋白既不是病毒粒子結(jié)構(gòu)成分又不是病毒RNA復制必需成分,因此,近年有較多研究關(guān)注于NS2對病毒包裝的影響.突變分析表明,NS2蛋白的N端保守位點及跨膜結(jié)構(gòu)對病毒包裝至關(guān)重要,C端蛋白酶蛋白酶結(jié)構(gòu)域而非其蛋白酶活性為病毒包裝所需.此外,NS2蛋白與病毒結(jié)構(gòu)蛋白,非結(jié)構(gòu)蛋白以及多種宿主因子存在相互作用,并在病毒包裝過程中形成多種復合體,本文對這些研究進行了歸納總結(jié).
[Abstract]:Hepatitis C virus (HCV) is a single-stranded positive RNA virus, which is one of the main pathogens leading to chronic hepatitis.Important advances in the study of HCV molecular biology after successful construction of in vitro culture system in recent years the steps of HCV life cycle have been thoroughly studied.Since NS2 protein is neither a structural component of virus particles nor an essential component of viral RNA replication, there have been more studies on the effect of NS2 on viral packaging in recent years.Mutation analysis showed that the N-terminal conserved site and transmembrane structure of NS2 protein were very important for virus packaging and the protease domain of C terminal was not the protease activity needed for virus packaging.In addition, NS2 protein interacts with virus structural protein, nonstructural protein and many host factors, and forms multiple complexes in the course of virus packaging. These studies are summarized in this paper.
【作者單位】： 中國人民解放軍武漢療養(yǎng)院;中國科學院武漢病毒研究所;中國科學院大學;
【基金】：國家自然科學基金資助項目(31200135)
【分類號】：R512.63

【共引文獻】

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本文編號：1749418