本文選題：非免疫缺陷　切入點(diǎn)：肺隱球酵母菌　出處：《中華醫(yī)院感染學(xué)雜志》2015年12期

【摘要】：目的研究非免疫缺陷肺隱球酵母菌病好轉(zhuǎn)的臨床特點(diǎn),分析其臨床特征和診斷方法,提高對(duì)肺隱球酵母菌病的認(rèn)識(shí)和診治水平。方法回顧性分析2009-2014年20例非免疫缺陷肺隱球酵母菌病患者的臨床表現(xiàn)、影像學(xué)改變、實(shí)驗(yàn)室檢查、病理表現(xiàn)、治療與轉(zhuǎn)歸,研究數(shù)據(jù)采用SPSS13.0統(tǒng)計(jì)軟件進(jìn)行分析。結(jié)果 20例非免疫缺陷肺隱球酵母菌病患者中4例臨床表現(xiàn)不明顯,其主要臨床表現(xiàn)以咳嗽及乏力為主,肺部CT表現(xiàn)為近胸膜團(tuán)塊實(shí)變影9例、病灶周圍伴有暈征6例、空洞及縱隔淋巴結(jié)腫大各2例,分別占45.0%、30.0%、10.0%、10.0%,初診時(shí)誤診12例,誤診率高達(dá)60.0%;經(jīng)氟康唑或伏立康唑等抗真菌治療后,患者肺部病灶明顯吸收,隨訪未見其他臟器播散。結(jié)論非免疫缺陷肺隱球酵母菌病臨床癥狀較輕,近胸膜團(tuán)塊實(shí)變影及病灶周圍伴有暈征是其較常見的影像學(xué)表現(xiàn),氟康唑是治療的首選藥物,治療效果良好,愈后未見復(fù)發(fā)。
[Abstract]:Objective to study the clinical features of the improvement of nonimmune deficiency pulmonary cryptoglobulomycosis, analyze its clinical characteristics and diagnostic methods, and improve the understanding, diagnosis and treatment of pulmonary cryptoglobulomycosis.Methods the clinical manifestations, imaging changes, laboratory examination, pathological findings, treatment and outcome of 20 patients with non-immunodeficient pulmonary cryptoglobulomycosis from 2009 to 2014 were analyzed retrospectively. The data were analyzed by SPSS13.0 software.Results the clinical manifestations of 4 cases of nonimmunodeficient pulmonary cryptoglobulomycosis were not obvious. The main clinical manifestations were cough and fatigue. The CT findings of lung showed solid changes of proximal pleural mass in 9 cases and halo sign around the lesion in 6 cases.The cavity and mediastinal lymph nodes were enlarged in 2 cases, accounting for 45.0% and 10.0%, 12 cases were misdiagnosed at first visit, the misdiagnosis rate was as high as 60.0.After antifungal therapy such as fluconazole or voriconazole, the pulmonary lesions were absorbed obviously, but no other organs were spread during follow-up.Conclusion the clinical symptoms of nonimmunodeficient pulmonary cryptoglobulomycosis are mild, the near pleural mass consolidation and the surrounding halo sign are the most common imaging manifestations of the disease. Fluconazole is the first choice in the treatment of the disease. Fluconazole is the first drug in the treatment, and it has no recurrence after recovery.
【作者單位】： 金華市人民醫(yī)院呼吸內(nèi)科;
【基金】：浙江省科技廳研究基金資助項(xiàng)目(201301259)
【分類號(hào)】：R519

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 王美芳;王悅虹;;23例免疫功能健全宿主肺隱球菌病臨床分析[J];浙江實(shí)用醫(yī)學(xué);2012年03期

【共引文獻(xiàn)】

相關(guān)期刊論文 前2條

1 劉真真;呂曉菊;唐光敏;;10例非免疫缺陷宿主肺隱球菌病臨床分析[J];四川醫(yī)學(xué);2015年04期

2 徐寧;黃小萍;;免疫功能正常的肺隱球菌病19例臨床分析[J];中國(guó)鄉(xiāng)村醫(yī)藥;2013年22期

【二級(jí)參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 徐作軍;;肺隱球菌感染的診斷和治療[J];中華結(jié)核和呼吸雜志;2006年05期

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 顏淑敏;;與廣泛癌癥譜相關(guān)的免疫缺陷[J];英國(guó)醫(yī)學(xué)雜志(中文版);2007年05期

2 盛長(zhǎng)法,翁心華,徐肇s，

本文編號(hào)：1718600