本文選題：乙肝肝硬化　切入點(diǎn)：人臍帶間充質(zhì)干細(xì)胞　出處：《海南醫(yī)學(xué)院學(xué)報》2016年11期

【摘要】：目的:分析人臍帶間充質(zhì)干細(xì)胞輔助治療對乙肝肝硬化患者肝功能、纖維化指標(biāo)及炎癥程度的影響。方法:選取經(jīng)本院診治的乙肝肝硬化患者80例納入研究,按照接受治療方式不同,所有納入對象被分為觀察組及對照組各40例。對照組接受常規(guī)治療,觀察組接受人臍帶間充質(zhì)干細(xì)胞輔助治療,對比兩組肝功能指標(biāo)、肝纖維化指標(biāo)、炎癥相關(guān)指標(biāo)、病情相關(guān)指標(biāo)水平差異。結(jié)果:觀察組治療后血清ALB、GLB、A/G值高于對照組,α2-M、TB、APO-A1、GGT值低于對照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);觀察組治療后血清HA、LN、CIV、PⅢNP、PLD值均低于對照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);觀察組治療后血清TGF-β1、PCT、WBC、SIL-2R水平值均低于對照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);觀察組經(jīng)治療后血清FT3、ADP值高于對照組,NO、EGF、ADM、IR值低于對照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:乙肝肝硬化患者接受人臍帶間充質(zhì)干細(xì)胞輔助治療,可以優(yōu)化肝功能并抑制病情進(jìn)展,具有積極的臨床意義。
[Abstract]:Objective: to analyze the effect of human umbilical cord mesenchymal stem cells (HMSCs) on liver function, fibrosis index and inflammation in patients with hepatitis B. methods: 80 patients with hepatitis B cirrhosis treated in our hospital were included in the study. According to the different methods of treatment, all the subjects were divided into observation group (n = 40) and control group (n = 40). The control group received routine treatment, the observation group received human umbilical cord mesenchymal stem cell adjunct therapy, and the liver function index and hepatic fibrosis index were compared between the two groups. Results: after treatment, the level of serum ALBN GLBN A / G in the observation group was higher than that in the control group, and the GGT value of 偽 2-MN TBX APO-A1G was lower than that in the control group, the difference was statistically significant (P 0.05), and the serum levels of HALNNU CIVP 鈪，

本文編號：1684941