發(fā)布時間：2018-03-27 23:17

  本文選題：血必凈注射液　切入點(diǎn)：重癥腹腔感染　出處：《中藥材》2015年10期

【摘要】：目的:探討血必凈注射液輔助治療重癥腹腔感染對患者T淋巴細(xì)胞和樹突細(xì)胞的影響。方法:78例重癥腹腔感染患者隨機(jī)分為對照組和觀察組,兩組患者均接受常規(guī)治療,觀察組患者在常規(guī)治療的基礎(chǔ)上接受血必凈注射液治療。治療前及治療2周抽取患者靜脈血,采用流式細(xì)胞術(shù)測定T淋巴細(xì)胞和樹突細(xì)胞水平,記錄兩組患者入院時及治療2周時的APACHEⅡ評分和胃腸功能評分,比較兩組患者SIRS消退時間、腸功能恢復(fù)時間、住院時間、住院病死率及MODS發(fā)生率。結(jié)果:(1)治療2周時觀察組患者外周血CD3~+、CD4~+和CD4~+/CD8~+水平均較對照組患者顯著升高(P0.01),而CD8~+水平較對照組患者顯著降低(P0.01);(2)治療2周時觀察組患者外周血CD1α、CD80、CD83和CD86水平均較對照組患者顯著升高(P0.01);(3)治療2周時觀察組患者APACHEⅡ評分和胃腸功能評分均較對照組患者降低(P0.01);(4)觀察組患者腸功能恢復(fù)時間、SIRS消退時間和住院時間均較對照組患者顯著縮短(P0.01),MODS發(fā)生率和住院病死率較對照組患者顯著降低(P0.05)。結(jié)論:血必凈注射液輔助治療重癥腹腔感染具有較好的臨床療效,并能調(diào)節(jié)T淋巴細(xì)胞和樹突細(xì)胞進(jìn)而改善患者免疫功能。
[Abstract]:Objective: to investigate the effect of Xuebijing injection on T lymphocytes and dendritic cells in patients with severe abdominal infection. Methods: 78 patients with severe abdominal infection were randomly divided into two groups: control group and observation group. The patients in the observation group were treated with Xuebijing injection on the basis of routine treatment. Venous blood was drawn from the patients before and after 2 weeks of treatment. The levels of T lymphocytes and dendritic cells were measured by flow cytometry. The APACHE 鈪，

本文編號：1673698