本文選題：尖銳濕疣　切入點：人乳頭瘤病毒　出處：《中國全科醫(yī)學》2017年04期

【摘要】：目的了解我國內(nèi)地尖銳濕疣(CA)患者的人乳頭瘤病毒(HPV)感染狀況,并探討其影響因素。方法系統(tǒng)檢索Pub Med、Science Direct Online、中國知網(wǎng)、萬方數(shù)據(jù)知識服務(wù)平臺、維普網(wǎng)中關(guān)于我國內(nèi)地CA患者HPV檢測的文獻,檢索時間均為1990年1月—2013年12月。根據(jù)樣本量對各文獻HPV感染率進行加權(quán)合并,計算CA患者的HPV及各基因型合并感染率,并分析不同研究年份、研究地區(qū)CA患者的HPV合并感染率,采用多因素Logistic回歸分析探討CA患者感染/檢出HPV的影響因素。結(jié)果共納入文獻67篇,累計CA患者10 757例,感染HPV 9 328例(86.7%)。CA患者的HPV合并感染率為95.7%〔95%CI(95.2%,96.2%)〕,其中合并感染率較高的前3種基因型為HPV6/11〔81.2%,95%CI(77.1%,85.2%)〕、HPV6〔43.8%,95%CI(35.2%,52.5%)〕、HPV11〔38.3%,95%CI(32.8%,43.8%)〕。1990—2003、2004—2013年CA患者的HPV合并感染率分別為96.6%〔95%CI(95.8%,97.5%)〕、94.6%〔95%CI(94.0%,95.3%)〕;東、中、西部患者的HPV合并感染率分別為95.1%〔95%CI(94.4%,95.7%)〕、91.7%〔95%CI(89.3%,94.1%)〕、96.5%〔95%CI(95.4%,97.6%)〕。多因素Logistic回歸分析結(jié)果顯示,研究年份、研究地區(qū)、標本類型、診斷方法是CA患者感染/檢出HPV的影響因素(P0.05)。對不同基因型進行分析,結(jié)果顯示,研究年份、研究地區(qū)、標本類型、診斷方法是CA患者感染/檢出HPV6的影響因素,研究年份、研究地區(qū)為西部、標本類型、診斷方法是CA患者感染/檢出HPV11的影響因素,研究地區(qū)為中部、標本類型是CA患者感染/檢出HPV16的影響因素,研究地區(qū)、標本類型、診斷方法是CA患者感染/檢出HPV18的影響因素(P0.05)。結(jié)論我國內(nèi)地CA患者的HPV感染以HPV6、HPV11基因型為主,感染率近10年來有所下降,東部地區(qū)感染率較高。病理檢查確診、采用剝落細胞進行DNA檢測,可以提高CA患者的HPV檢出率。
[Abstract]:Objective to understand the Chinese mainland condyloma acuminatum (CA) in patients with human papilloma virus (HPV) infection, and to explore its influencing factors. Methods Pub Science Direct retrieval system of Med, Online, Chinese CNKI, Wanfang Data knowledge service platform, on the mainland of CA were detected by HPV literature in China VIP network, retrieval time is January 1990 to December 2013. According to the sample size of the literature HPV infection rate was weighted with HPV and CA were calculated, each genotype infection rate, and the analysis of different year of study, patients with CA of HPV infection rate, using multivariate Logistic regression analysis on Influence Factors of CA infection in patients with positive / HPV results. A total of 67 articles were included, a total of 10757 patients with CA infection, 9328 cases of HPV (86.7%).CA patients with HPV infection rate was 95.7%, 95%CI (95.2%, 96.2%), with a sense of former 3 genotypes of high infection rate For HPV6/11 81.2%, 95%CI (77.1%, 85.2%), HPV6 43.8%, 95%CI (35.2%, 52.5%), HPV11 38.3%, 95%CI (32.8%, 43.8%).1990 - 20032004 - 2013 CA patients with HPV combined infection rate were 96.6% 95%CI (95.8%, 97.5%, 94.6% (95%CI) 94%, 95.3%); in the East, West, patients with HPV combined infection rate was 95.1%, 95%CI (94.4%, 95.7%), 91.7% 95%CI (89.3%, 94.1%), 96.5% 95%CI (95.4%, 97.6%). Multivariate Logistic regression analysis showed that the year of study, the research area. The specimen type, diagnosis methods are influencing factors of infection in patients with CA / HPV (P0.05). The detection of different genotypes were analyzed, results showed that year of study, study area, specimen type, diagnosis methods are influencing factors of infection in patients with CA / HPV6 detection, years of research, the research for the western regions, the specimen type, diagnosis the method is CA / HPV11 infection detection The influence factors, the study area is central, specimen type is CA infection in patients with / out the factors that influence HPV16 research area, specimen type, diagnosis methods are influencing factors of infection in patients with CA / HPV18 detection (P0.05). Conclusion the mainland of China CA HPV infected patients with HPV6, HPV11 gene type, infection rate nearly 10 years of decline, a higher rate of infection. The eastern region confirmed by pathological examination, were used to detect DNA cell exfoliation, can improve the detection rate of HPV in patients with CA.

【作者單位】： 廈門大學公共衛(wèi)生學院;衛(wèi)生技術(shù)評估福建省高校重點實驗室;廈門大學經(jīng)濟學院;
【基金】：福建省自然科學基金青年項目(2014J05097)
【分類號】：R737.33;R752.53

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本文編號：1660566