發(fā)布時(shí)間：2018-03-21 23:21

  本文選題：復(fù)發(fā)性單純皰疹　切入點(diǎn)：序貫療法　出處：《安徽中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：1目的本研究旨在觀察中西藥序貫療法治療復(fù)發(fā)性單純皰疹臨床療效,對(duì)比觀察對(duì)縮短皮損愈合時(shí)間及復(fù)發(fā)次數(shù)的影響。觀察中西藥序貫療法治療復(fù)發(fā)性單純皰疹的有效性和安全性,以期找到一種對(duì)復(fù)發(fā)性單純皰疹的有效的治療方案以降低復(fù)發(fā)頻率。2方法62例納入課題研究的患者隨機(jī)分為各31例的治療組和對(duì)照組。治療組予以伐昔洛韋300mg bid,共5d,后繼服8周中藥(大青葉15g、白花蛇舌草10g、板藍(lán)根15g、金銀花10g、連翹10g、黨參10g、黃芪10g、白術(shù)10g、當(dāng)歸10g、女貞子15g、墨旱蓮15g、薏苡仁30g、生甘草10g;日一劑,水煎分服);對(duì)照組予以伐昔洛韋300mg bid,共5d。同時(shí)兩組均針對(duì)皮損予以局部外用藥進(jìn)行對(duì)癥處理。兩組治療結(jié)束后均觀察6個(gè)月,記錄每次復(fù)發(fā)皮損變化及每個(gè)月病情變化,并于觀察期結(jié)束后比較兩組患者皮損評(píng)分、中醫(yī)證候評(píng)分、復(fù)發(fā)情況、遠(yuǎn)期療效、焦慮情況、DLQI評(píng)分,同時(shí)觀察整個(gè)研究過(guò)程中有無(wú)不良反應(yīng)。3結(jié)果比較兩組治療后的復(fù)發(fā)情況,4個(gè)月,(49)=0.032;6個(gè)月,(49)=0.037,((49)0.05),差異均有統(tǒng)計(jì)學(xué)意義,治療組在減少?gòu)?fù)發(fā)情況上治療組優(yōu)于僅服用伐昔洛韋的對(duì)照組。比較兩組遠(yuǎn)期療效,治療后6個(gè)月,治療組無(wú)效5例,有效8例,顯效17例,總有效率83.33%;對(duì)照組無(wú)效6例,有效15例,顯效9例,總有效率80%,(49)=0.046,(49)0.05,差異具有統(tǒng)計(jì)學(xué)意義,治療組遠(yuǎn)期療效優(yōu)于對(duì)照組。兩組治療前一般情況、皮損評(píng)分和愈合時(shí)間、中醫(yī)證候評(píng)分、DLQI評(píng)分、半年復(fù)發(fā)次數(shù)均具有可比性,差異無(wú)統(tǒng)計(jì)學(xué)意義,治療前后皮損情況相比,均可改善皮損且療效相當(dāng),并且在治療后1周皮損愈合上均有所改善。兩組治療前后中醫(yī)證候評(píng)分治療組效果明顯優(yōu)于對(duì)照組,在對(duì)患者生活質(zhì)量和焦慮抑郁的改善,治療組效果亦優(yōu)于對(duì)照組。治療期間,治療組有1例經(jīng)期延期、1例輕度胃炎反應(yīng),對(duì)照組僅有1例腹瀉。兩組不良反應(yīng)發(fā)生率分別為6.67%、3.33%,無(wú)統(tǒng)計(jì)學(xué)意義。4結(jié)論中西藥序貫療法治療復(fù)發(fā)性單純皰疹有確切的臨床療效,優(yōu)勢(shì)在于可有效降低復(fù)發(fā)頻率且無(wú)明顯不良反應(yīng),值得在臨床推廣。
[Abstract]:Objective to observe the clinical effect of sequential therapy of Chinese and western medicine on recurrent herpes simplex. The effect of sequential therapy of Chinese and western medicine on the treatment of recurrent herpes simplex was observed. In order to find an effective treatment for recurrent herpes simplex, 62 patients included in the study were randomly divided into treatment group (n = 31) and control group (n = 31). The treatment group was treated with valciclovir 300mg bidbid. A total of 5 days, followed by 8 weeks of traditional Chinese medicine (Daqingye 15g, white hyacinth 10g, Isatis lanceolata 15g, honeysuckle 10g, Forsythia 10g, Codonopsis 10g, Astragalus 10g, Atractylodes macrocephala 10g, Angelica sinensis 10g, Ligustrum lucidum 15g, Upland lotus 15g, Coix seed 30g, raw liquorice 10g; The patients in the control group were treated with 300mg bidae for 5 days. Both groups were treated with local external medicine for the skin lesions. The patients in both groups were observed for 6 months after the treatment, and the changes of the recurrent lesions and the monthly changes of the disease were recorded. At the end of the observation period, the scores of skin lesions, TCM syndromes, recurrence, long-term effects, anxiety and DLQI were compared between the two groups. At the same time, we observed whether there were adverse reactions in the whole course of the study and compared the recurrence rate of the two groups after treatment, 4 months after treatment and 0.032 months after treatment, and 6 months after treatment, there were significant differences between the two groups. In reducing recurrence, the treatment group was better than the control group which only took valaciclovir. After 6 months of treatment, the treatment group had no effect in 5 cases, effective in 8 cases, remarkable effect in 17 cases, the total effective rate was 83.33 cases, while the control group had no effect in 6 cases. There were 15 cases of effective and 9 cases of remarkable effect. The total effective rate was 80%. The difference was statistically significant. The long-term curative effect of the treatment group was better than that of the control group. The general situation before treatment, the score of skin lesion and healing time, the score of TCM syndromes and DLQI score in the two groups were better than those in the control group. The number of recurrence in half a year was comparable, but the difference was not statistically significant. Compared with before and after treatment, the number of recurrent lesions could be improved and the curative effect was similar. The curative effect of the treatment group was obviously better than that of the control group before and after treatment, and the quality of life and anxiety and depression of the patients were improved. The effect of the treatment group was also better than that of the control group. During the treatment period, there was 1 case of delayed menstrual period and 1 case of mild gastritis in the treatment group. There was only one case of diarrhea in the control group. The incidence of adverse reactions in the two groups was 6.67 and 3.33, respectively. No statistical significance was found in the treatment of recurrent herpes simplex with sequential therapy of Chinese and western medicine. The advantage is that it can reduce the recurrence frequency effectively and has no obvious adverse reaction, so it is worth popularizing in clinic.
【學(xué)位授予單位】：安徽中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R752.11

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李其林;;生殖器皰疹的規(guī)范化診治[J];皮膚病與性病;2016年04期

2 陳福祥;王鎦;林旭鋒;;自擬中藥養(yǎng)陰扶正解毒方聯(lián)合胸腺肽腸溶片治療復(fù)發(fā)性生殖器皰疹療效觀察[J];華夏醫(yī)學(xué);2015年05期

3 瞿俊勇;田夢(mèng);賀建華;劉湘新;;白花蛇舌草多糖對(duì)免疫抑制小鼠的免疫調(diào)節(jié)作用研究[J];中藥材;2015年09期

4 楊婧妍;何立巍;董偉;;板藍(lán)根正丁醇部位對(duì)免疫細(xì)胞增殖及體外抗氧化活性的研究[J];南京中醫(yī)藥大學(xué)學(xué)報(bào);2015年02期

5 何立巍;楊婧妍;董偉;秦瑩亞;;板藍(lán)根乙酸乙酯部位體外抗病毒活性研究[J];藥學(xué)研究;2015年01期

6 王亞丹;楊建波;戴忠;馬雙成;;中藥金銀花的研究進(jìn)展[J];藥物分析雜志;2014年11期

7 劉亭亭;王萌;;女貞子化學(xué)成分與藥理作用研究進(jìn)展[J];中國(guó)實(shí)驗(yàn)方劑學(xué)雜志;2014年14期

8 樸紅梅;宋秋紅;金延燕;鄭明昱;延光海;;白花蛇舌草對(duì)哮喘模型小鼠Th1/Th2免疫平衡的影響[J];中國(guó)醫(yī)院藥學(xué)雜志;2013年17期

9 呂峰;林勇毅;陳代園;;薏苡仁活性多糖對(duì)小鼠的免疫調(diào)節(jié)作用[J];中國(guó)食品學(xué)報(bào);2013年06期

10 左婭;朱慧娟;劉軍;代明;;板藍(lán)根多糖抗單純皰疹病毒Ⅱ型的實(shí)驗(yàn)研究[J];華西藥學(xué)雜志;2013年03期

相關(guān)重要報(bào)紙文章 前1條

1 張驍;束梅英;;女貞子藥理研究進(jìn)展[N];中國(guó)醫(yī)藥報(bào);2004年

相關(guān)碩士學(xué)位論文 前1條

1 馮艷艷;中醫(yī)治療對(duì)生殖器皰疹復(fù)發(fā)性的臨床療效觀察[D];廣州中醫(yī)藥大學(xué);2015年

，

本文編號(hào)：1646028