本文選題：乙型肝炎　切入點(diǎn)：慢性乙型肝炎　出處：《中國感染控制雜志》2017年10期 　論文類型：期刊論文

【摘要】：目的探討直接抗人球蛋白試驗(yàn)(DAT)陽性在慢性重型乙型肝炎患者貧血中的臨床意義。方法對30例健康人、30例慢性乙型肝炎(慢乙肝)患者和50例慢性重型乙型肝炎(慢重肝)患者紅細(xì)胞相關(guān)參數(shù)及DAT進(jìn)行檢測,并對影響DAT陽性的臨床相關(guān)因素進(jìn)行分析。結(jié)果慢重肝患者紅細(xì)胞計(jì)數(shù)、血紅蛋白(Hb)濃度以及紅細(xì)胞壓積(HCT)均低于慢乙肝患者和健康組(P0.05),而慢重肝患者紅細(xì)胞體積分布寬度(RDW)高于慢乙肝和健康組(P0.05);慢重肝患者、慢乙肝患者和健康組DAT陽性率分別為62.82%、13.33%和0。DAT陽性的慢重肝患者紅細(xì)胞計(jì)數(shù)、Hb濃度和HCT均低于相應(yīng)DAT陰性患者(均P0.05),RDW卻高于DAT陰性慢重肝患者(P=0.001);慢重肝患者紅細(xì)胞毛細(xì)管分離后,衰老紅細(xì)胞的DAT陽性強(qiáng)度高于年輕紅細(xì)胞DAT陽性強(qiáng)度(P0.001);在慢重肝患者中,DAT的陽性和陰性的患者在性別、年齡、丙氨酸氨基轉(zhuǎn)移酶、總膽紅素、補(bǔ)體C3、C-反應(yīng)蛋白及是否并發(fā)糖尿病方面存在差異(均P≤0.05)。結(jié)論慢重肝患者貧血的產(chǎn)生可能與衰老紅細(xì)胞吸附抗體所致的免疫性溶血有關(guān)。
[Abstract]:Objective to investigate the clinical significance of direct antiglobulin test (DAT-positive) in anemia in patients with chronic severe hepatitis B. methods 30 healthy people with chronic hepatitis B and 50 patients with chronic severe hepatitis B were enrolled in this study. RBC related parameters and DAT were measured in patients with chronic and severe liver. The related factors affecting DAT positive were analyzed. Results the red blood cell count in patients with chronic severe liver, The concentrations of HB and HCT were lower in patients with chronic hepatitis B and healthy persons than those in patients with chronic hepatitis B and healthy persons, while the RDWs of erythrocyte volume distribution in patients with chronic and heavy liver were higher than those in patients with chronic hepatitis B and healthy persons, while those in patients with chronic and severe liver were higher than those in patients with chronic hepatitis B and healthy persons. The positive rates of DAT in patients with chronic hepatitis B and healthy subjects were 62.82% and 0.DAT-positive, respectively. The red blood cell count HB and HCT in patients with chronic hepatitis B and healthy subjects were lower than those in patients with DAT negative (all P0.05rdw were higher than those in patients with DAT negative chronic and severe liver (P 0.001), red blood cell capillary separation in patients with chronic and severe liver was higher than that in patients with chronic and severe liver. The positive intensity of DAT in aging erythrocytes was higher than that in young erythrocytes (P 0.001). In patients with chronic liver disease, the positive and negative DAT levels were higher in sex, age, alanine aminotransferase, total bilirubin, total bilirubin, and alanine aminotransferase. There were significant differences in complement C3C- reactive protein and diabetes mellitus (all P 鈮，

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