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  本文選題：FIB-指數　切入點：肝纖維化　出處：《安徽醫(yī)科大學學報》2015年06期 　論文類型：期刊論文

【摘要】：目的探討FIB-4指數對谷丙轉氨酶(ALT)小于2倍正常值上限的慢性乙型肝炎病毒(HBV)感染患者肝纖維化程度的診斷價值。方法對416例ALT小于2倍正常值上限的慢性HBV感染患者進行肝臟穿刺病理檢查,同時檢測肝穿當天患者的ALT、谷草轉氨酶(AST)、血小板等指標。根據FIB-4計算公式得出FIB-4指數值,以肝穿病理結果為金標準繪制FIB-4指數的受試者工作特征曲線(ROC),計算曲線下面積,評價FIB-4指數對顯著肝纖維化、嚴重肝纖維化和肝硬化的預測價值。結果隨著肝纖維化程度的加重,FIB-4指數逐步升高,在S1~S4 4組間差異有統(tǒng)計學意義(P0.05)。E抗原陽性與陰性患者的FIB-4指數比較差異有統(tǒng)計學意義(P0.05)。E抗原陽性患者診斷顯著肝纖維化、嚴重肝纖維化、肝硬化的FIB-4指數截斷值分別為1.283、1.283和1.449,分別對應不同的靈敏度和特異度。而在E抗原陰性的患者中,其相應的截斷值為2.094、2.094和2.415。結論 FIB-4指數對于ALT小于2倍正常值上限的慢性HBV感染患者是一種簡單、有效的無創(chuàng)肝纖維化評價指標,可使大部分患者避免肝穿活檢。
[Abstract]:Objective to investigate the diagnostic value of FIB-4 index for hepatic fibrosis in patients with chronic hepatitis B virus (HBV) infection whose alt is less than 2 times the upper limit of normal value. Methods 416 cases of chronic HBV infection with ALT less than 2 times the upper limit of normal value were studied. The patient underwent liver biopsy and pathological examination. At the same time, the alt, alt, AST, platelet and so on were detected. According to the FIB-4 formula, the FIB-4 index was obtained. The operating characteristic curve of FIB-4 index was drawn according to the pathological results of liver puncture as gold standard, and the area under the curve was calculated. To evaluate the predictive value of FIB-4 index for significant hepatic fibrosis, severe hepatic fibrosis and liver cirrhosis. Results the FIB-4 index increased gradually with the severity of hepatic fibrosis. There was significant difference in FIB-4 index between S1-S44 group and P0.05Ag-positive group. There was significant difference in FIB-4 index between P0.05Ag-E antigen positive group and S1-S44 group. There was a significant difference in the diagnosis of liver fibrosis and severe hepatic fibrosis in patients with positive P0.05-E antigen. The truncation values of FIB-4 index in cirrhosis were 1.283 and 1.449, respectively, corresponding to different sensitivity and specificity. The corresponding truncation values were 2.094n2.094 and 2.415.Conclusion FIB-4 index is a simple and effective non-invasive index for evaluating liver fibrosis in patients with chronic HBV infection whose ALT is less than 2 times the upper limit of normal value, and can make most patients avoid liver biopsy.
【作者單位】： 安徽醫(yī)科大學第二附屬醫(yī)院肝病科;
【基金】：安徽高校省級自然科學基金(編號:KJ2014A107)
【分類號】：R512.62

【參考文獻】

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本文編號：1577571