發(fā)布時間：2018-02-28 22:31

  本文關(guān)鍵詞： 胰腺癌 慢性 乙型肝炎　出處：《重慶醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：乙型肝炎病毒感染是一個全球性的健康問題。據(jù)世界衛(wèi)生組織2008年統(tǒng)計，全世界的乙肝病毒攜帶者超過3.5億人，，亞洲、太平洋地區(qū)是高發(fā)地區(qū)，全球每年因患乙肝相關(guān)性疾病死亡的人數(shù)有500,000-700,000人。胰腺癌作為一個高度惡性的腫瘤，他的致病因素，目前還不完全明確。因此，此項研究對乙肝病毒感染與胰腺癌之間的關(guān)系進行了分析。 方法：檢索了PUBMED,Web of knowledge, EMBASE,Cohchrane,萬方、CNKI、維普全文數(shù)據(jù)庫等，納入乙肝病毒感染與胰腺癌有關(guān)的病例對照研究，并采用RevMan5.0軟件對符合納入標準的6個研究通過固定效應(yīng)模型或者隨機效應(yīng)模型進行薈萃分析。 結(jié)果：薈萃分析結(jié)果顯示：胰腺癌組中乙肝表面抗原的陽性率高于健康對照組(8.87%vs5.86%, OR=1.24,95%CI=1.06-1.47, P=0.009)；乙肝表面抗原以及乙肝核心抗體陰性率胰腺癌組低于健康對照組(69.4%vs77.1%, OR=0.68,95%CI=0.51-0.92, P=0.01)；而乙肝e抗原陽性率無統(tǒng)計學(xué)差異（P=0.550.05）。 結(jié)論：乙肝病毒感染特別是乙肝表面抗原陽性可以增加胰腺癌的發(fā)病風險。
[Abstract]:Objective: hepatitis B virus infection is a global health problem. According to the statistics of the World Health Organization in 2008, there are more than 350 million people living with hepatitis B virus in the world. There are 500, 000-700, 000 deaths per year in the world from hepatitis B related diseases. Pancreatic cancer, as a highly malignant tumor, is a cause that is not entirely clear. The study analyzed the relationship between hepatitis B virus infection and pancreatic cancer. Methods: we searched PUBMEDU Web of knowledge, EMBASE Cohchrane, Wanfang CNKI, Weip full-text database, and included in the case-control study of hepatitis B virus infection and pancreatic cancer. A meta-analysis of 6 studies that meet the inclusion criteria is carried out by using RevMan5.0 software through either the fixed effect model or the random effect model. Results: the results of meta-analysis showed that the positive rate of hepatitis B surface antigen in pancreatic cancer group was higher than that in healthy control group (8.87 vs 5.86), OR1. 2495 CIQ 1.06-1.47, P0. 009, the negative rate of hepatitis B surface antigen and hepatitis B core antibody in pancreatic cancer group was lower than that in healthy control group (69.4 vs77.1, OR0.6895CII 0.51-0.92, P0. 01), and the positive rate of HBV surface antigen and hepatitis B core antibody negative pancreatic cancer group was lower than that of healthy control group (69.4 vs77.1, OR0.6895CII 0.51-0.92). There was no statistical difference in the positive rate of hepatitis B e antigen. Conclusion: hepatitis B virus infection, especially hepatitis B surface antigen positive, can increase the risk of pancreatic cancer.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R512.62;R735.9

【參考文獻】

相關(guān)期刊論文 前4條

1 劉奇才;郜峰;程祖建;廖冬妹;歐啟水;;戊型肝炎病毒感染與胰腺癌發(fā)生的關(guān)系[J];檢驗醫(yī)學(xué)與臨床;2007年11期

2 時德仁;陸立;王建華;東傳凌;叢聞天;;肝硬變患者肝胰組織中HBV DNA的分布[J];世界華人消化雜志;2000年07期

3 趙東;周清華;;乙肝相關(guān)性腎炎的治療[J];中國病原生物學(xué)雜志;2008年11期

4 ;Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance[J];World Journal of Gastroenterology;2000年06期

本文編號：1549280