發(fā)布時(shí)間：2018-02-09 19:44

  本文關(guān)鍵詞： 中性粒細(xì)胞CD 乙肝肝硬化 自發(fā)性細(xì)菌性腹膜炎 抗生素　出處：《中國現(xiàn)代醫(yī)學(xué)雜志》2017年19期 　論文類型：期刊論文

【摘要】：目的探討中性粒細(xì)胞CD64對(duì)乙肝肝硬化并發(fā)自發(fā)性細(xì)菌性腹膜炎(SBP)應(yīng)用抗生素的指導(dǎo)價(jià)值。方法將134例乙肝肝硬化并發(fā)SBP患者隨機(jī)分為CD64組(73例)和對(duì)照組(61例),CD64組根據(jù)中性粒細(xì)胞CD64作為開始和停用抗生素的依據(jù);對(duì)照組按照常規(guī)方法應(yīng)用抗生素。比較兩組患者的抗生素療程、抗生素費(fèi)用、住院時(shí)間、住院費(fèi)用、Child-Pugh評(píng)分、MELD評(píng)分、臨床有效率及病死率。結(jié)果 CD64組抗生素療程8 d(6~14 d)、抗生素費(fèi)用781元(458~4 297元)、住院時(shí)間15 d(6~29 d)、住院費(fèi)用7 328元(4 951~13 916元)均低于對(duì)照組分別為11 d(7~20 d),1 084元(728~5 822元),20 d(10~35 d),10 239元(5 325~19 824元)。治療結(jié)束后CD64組與對(duì)照組患者Child-pugh評(píng)分[(9.26±3.24)vs(9.72±3.12)]、MELD評(píng)分[(16.16±8.04)vs(15.71±8.13)]、臨床有效率(90.41%vs 91.80%)和病死率(4.11%vs 3.28%)比較,均差異無統(tǒng)計(jì)學(xué)意義(均P0.05)。結(jié)論中性粒細(xì)胞CD64可作為乙肝肝硬化并發(fā)SBP患者臨床抗生素應(yīng)用的參考指標(biāo),并能夠縮短抗生素使用時(shí)間和住院天數(shù)。
[Abstract]:Objective to investigate the value of neutrophil CD64 in the application of antibiotics in patients with hepatitis B cirrhosis complicated with spontaneous bacterial peritonitis. Methods 134 patients with hepatitis B cirrhosis complicated with SBP were randomly divided into CD64 group (n = 73) and control group (n = 61). Neutrophil CD64 was used as the basis for the initiation and discontinuation of antibiotics. The patients in the control group were treated with antibiotics according to the routine method. The course of antibiotic treatment, the cost of antibiotics, the length of hospitalization, the Child-Pugh score and meld score were compared between the two groups. Results the clinical effective rate and mortality rate in CD64 group were lower than those in control group (11 days, 720 days, 1084 days, 781 yuan, 458min, 4297 yuan, 15 days, 629 days, 7 328 yuan / 4 951U 13 916), respectively, which were lower than those in the control group (11 days, 720 days, 1 084 days, 728 yuan, 5 822 yuan), respectively, in the CD64 group, the course of antibiotic treatment was 8 days, the course of treatment was 6 days, the cost of antibiotics was 781 yuan, the cost of antibiotics was 4 297 yuan. After treatment, the Child-pugh score of CD64 group and control group [9.26 鹵3.24 vs 9.72 鹵3.12)] meld score [16.16 鹵8.04 vs 15.71 鹵8.13], the clinical effective rate was 90.41 vs 91.80) and the mortality was 4.11m vs 3.28). Conclusion neutrophil CD64 can be used as a reference index for the clinical use of antibiotics in patients with hepatitis B cirrhosis complicated with SBP, and can shorten the duration of antibiotic use and hospital stay.
【作者單位】： 福建醫(yī)科大學(xué)孟超肝膽醫(yī)院(福州市傳染病醫(yī)院);
【基金】：福州市衛(wèi)生系統(tǒng)科技計(jì)劃項(xiàng)目(No:2016-S-wq7)
【分類號(hào)】：R512.62;R572.2;R575.2
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本文編號(hào)：1498710